Physiologic regulators of bone turnover in young women with anorexia nervosa
Physiologic regulators of bone turnover in young women with anorexia nervosa
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DOI：
10.1067/mpd.2002.125003
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发表时间：
2002-07-01
影响因子：
5.1
通讯作者：
LeBoff, MS
中科院分区：
文献类型：
--
作者：
Gordon, CM;Goodman, E;LeBoff, MS
目的：为了澄清的作用，生理调节剂的骨转换患者神经性厌食症（AN）。研究设计：青春期女孩与AN（n = 61）的人体测量，营养，和运动数据采集，骨密度（BMD）和身体组成的双能X线吸收测定法测量。血清样本用于激素、促吸收细胞因子和骨形成标记物，尿液用于骨吸收标记物。结果：在双变量相关分析中，腰椎BMD的显著（P <0.05）预测因素包括身高、体重和运动。在多元回归模型中，即使在控制了闭经和AN的持续时间后，这些显著的关系仍然存在。对于全身BMD，发现了相同的正预测因子，而体脂百分比是负相关的。对于髋部骨密度，运动和体重被发现是积极的预测因素。硫酸脱氢表雄酮（DHEAS）与N-端肽（NTx）呈负相关，胰岛素样生长因子1（IGF-I）与骨钙素直接相关。促吸收细胞因子水平低或检测不到。结论：运动和体重是BMD的积极预测因素。这些数据是第一次提出DHEAS和AN骨吸收增加之间的关系。IGF-I与骨形成指标相关。低细胞因子水平表明，这些因素不介导AN的骨吸收增加。（J Pediatr 2002; 141：64 - 70）。
Objective: To clarify the role of physiologic regulators of bone turnover in patients with anorexia nervosa (AN).Study design: Adolescent girls with AN (n = 61) had anthropometric, nutrition, and exercise data acquired, and bone mineral density (BMD) and body composition measured by dual energy x-ray absorptiometry. Serum samples were obtained for hormones, proresorptive cytokines, and bone formation markers, and urine for bone resorption markers.Results: In bivariate correlation analyses, significant (P < .05) predictors of lumbar BMD included height, weight, and exercise. In multiple regression models, these significant relationships held, even after controlling for the duration of amenorrhea and AN. For total body BMD, the same positive predictors were found and percentage of body fat was a negative correlate. For hip BMD, exercise and weight were found to be positive predictors. Dehydroepiandrosterone sulfate (DHEAS) was inversely correlated with N-telopeptides (NTx), and insulin-like growth factor 1 (IGF-I) was directly correlated with osteocalcin. Proresorptive cytokine levels were low or undetectable.Conclusions: Exercise and weight were positive predictors of BMD. These data are the first to suggest a relationship between DHEAS and increased bone resorption in AN. IGF-I was correlated with bone formation indices. Low cytokine levels suggest that these factors do not mediate the increased bone resorption of AN. (J Pediatr 2002;141:64-70).