The NO-releasing Heterocycles
The NO-releasing Heterocycles
复制标题
DOI：
10.1002/3527603751.ch6
复制
发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Schoenafinger, Karl
中科院分区：
文献类型：
--
作者：
Gasco, Alberto;Schoenafinger, Karl
在许多评论中，该主题已被视为 NO 捐助者一般讨论的一部分 [1-4]。本章将简要介绍这些系统的一般性质以及合成它们的主要方法，然后重点介绍它们的NO供体性质和NO依赖性生物活性。 NO 一词在此用作家族名称，不仅包括一氧化氮 (NO•)，还包括其两种氧化还原形式，硝酰基 (HNO) 和亚硝鎓离子 (NO+)，它们在与 NO•相关的复杂信号系统中发挥着重要作用[5]。如果已知的话，在讨论需要时将指出参与 NO 释放的具体氧化还原形式。
The subject has been treated as part of a general discussion of NO-donors in a number of reviews [1–4]. This chapter will briefly introduce the general properties of these systems and the chief methods to synthesise them, after which it will concentrate on their NO-donor properties and NO-dependent biological activities. The term NO will be used here as a family name, embracing not only nitric oxide (NO•) but also its two redox forms, nitroxyl (HNO) and nitrosonium ion (NO+), which play important roles in the complex signalling system connected with NO•[5]. The specific redox form involved in the NO-release will be indicated, if known, when necessary for the discussion.