Biodistribution and estimation of radiation-absorbed doses in humans for 13N-ammonia PET
Biodistribution and estimation of radiation-absorbed doses in humans for 13N-ammonia PET
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DOI：
10.1007/s12149-015-1012-4
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发表时间：
2015-08
影响因子：
2.6
通讯作者：
C. Yi;Donglan Yu;Xinchong Shi;Qiao He;Xuezhen Zhang;Xiangsong Zhang
中科院分区：
文献类型：
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作者：
C. Yi;Donglan Yu;Xinchong Shi;Qiao He;Xuezhen Zhang;Xiangsong Zhang
目的探讨13N-氨辐射吸收剂量在健康人体内的生物分布。方法5名健康受试者注射555-740亿MBq的13N-氨后进行全身正电子发射计算机断层扫描和CT扫描。对每名健康志愿者进行5次连续动态发射扫描。在CT图像上绘制感兴趣区域，并将其传输到相应的横断PET切片。结果13N-氨在心脏和肝脏中的浓度最高，其次是胰腺、脑、脾和胃。器官吸收剂量以心壁(7.14E−03)和肾脏(6.02E−03)最高(7.14E−03和3.63E−03)。有效剂量(ED)为6.58E−03±1.23E−03 mSv/MBq。结论根据13N-氨剂量学的新估算，中国人的结果与以前用旧装置进行的研究没有显著差异。作为最重要的心肌灌注PET示踪剂之一，全身13N-氨PET似乎对人类是安全的，产生的辐射负担相对较小，允许每年对同一主题进行多项PET研究。
ObjectiveTo evaluate the biodistribution of radiation-absorbed doses of13N-ammonia in healthy people.MethodsFive healthy human subjects underwent whole-body PET and CT scans after injection of 555–740 MBq of13N-ammonia. Five serial dynamic emission scans in each healthy volunteer were acquired. Regions of interest were drawn on the CT image and transferred to the corresponding transverse PET slice. Estimates of the radiation-absorbed doses were calculated using the medical internal radiation dosimetry method.ResultsThe highest concentrations of13N-ammonia were found in the heart and liver, followed by pancreas, brain, spleen and stomach. The highest absorbed organ doses were to the heart wall (7.14E−03 ± 3.63E−03 mGy/MBq) and kidneys (6.02E−03 ± 3.53E−03 mGy/MBq). The effective dose (ED) was 6.58E−03 ± 1.23E−03 mSv/MBq.ConclusionsWith these new estimates for13N-ammonia dosimetry, the results for Chinese people were not appreciably different from those of the previous study performed with old devices. As one of the most important myocardial perfusion PET tracers, the whole-body13N-ammonia PET appears to be safe for humans, yielding a relatively modest radiation burden that would allow multiple PET studies on the same subject per year.