Neoangiogenesis induced by progenitor endothelial cells: effect of fucoidan from marine algae.
Neoangiogenesis induced by progenitor endothelial cells: effect of fucoidan from marine algae.
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内皮祖细胞诱导的新血管生成：海藻中岩藻依聚糖的作用。
DOI：
10.2174/187152507779315778
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发表时间：
2007
影响因子：
--
通讯作者：
Anne
中科院分区：
文献类型：
--
作者：
C. Boisson‐Vidal;F. Zemani;G. Caligiuri;I. Galy;Sylvia Colliec;D. Helley;Anne
岩藻多糖——从褐藻中提取的硫酸化多糖——可能对缺血性疾病患者有益。它们的抗血栓和促血管生成特性可促进动物的新血管形成和血管生成，从而防止缺血组织坏死。 1997年，首次在人外周血中鉴定出内皮祖细胞。它们是从骨髓中招募的，有助于缺血性损伤后的新血管形成。这些细胞在缺血部位的动员是新血管形成的重要步骤。据认为，祖细胞与内皮细胞相互作用，然后外渗并到达缺血部位，在那里它们增殖并分化成新血管。尽管趋化因子、细胞因子和粘附分子被认为参与其中，但祖细胞动员的精确机制尚不完全清楚。最近的研究表明基质衍生因子 1 在祖细胞动员的几个步骤中发挥着关键作用。鉴于蛋白多糖在骨髓内、内皮表面以及在生长因子和趋化因子结合中的作用，岩藻依聚糖可能影响内皮祖细胞的动员及其在缺血组织中的掺入。本综述提供了循环内皮祖细胞及其在新生血管形成中的作用的最新信息。它重点介绍了我们对这些祖细胞和外源硫酸多糖之间相互作用的理解的最新进展，及其对理解岩藻依聚糖作用机制的影响。
Fucoidans--sulphated polysaccharides extracted from brown algae--could be beneficial in patients with ischemic diseases. Their antithrombotic and proangiogenic properties promote in animals, neovascularization and angiogenesis which prevent necrosis of ischemic tissue. In 1997, endothelial progenitor cells were first identified in human peripheral blood. They are recruited from bone marrow and contribute to neovascularization after ischemic injury. Mobilization of these cells in ischemic sites is an important step in new vessel formation. It is thought that the progenitors interact with endothelial cells, then extravasate and reach ischemic sites, where they proliferate and differentiate into new blood vessels. Although chemokines, cytokines and adhesion molecules are thought to be involved, the precise mechanism of progenitor mobilization is not fully understood. Recent studies suggest that stromal-derived factor 1 plays a critical role at several steps of progenitor mobilization. Given the role of proteoglycans within bone marrow, at the endothelium surface, and in growth factor and chemokine binding, fucoidans might influence the mobilization of endothelial progenitor cells and their incorporation in ischemic tissue. This review provides an update on circulating endothelial progenitors and their role in neovascularization. It focuses on recent advances in our understanding of interactions between these progenitor cells and exogenous sulphated polysaccharides, and their implications for understanding the fucoidan mechanism of action.