Effect of predatory stress on sucrose intake and behavior on the plus-maze in male mice
Effect of predatory stress on sucrose intake and behavior on the plus-maze in male mice
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DOI：
10.1016/s0031-9384(99)00051-7
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发表时间：
1999-08-15
影响因子：
2.9
通讯作者：
Martinez, M
中科院分区：
文献类型：
--
作者：
Calvo-Torrent, A;Brain, PF;Martinez, M
在本研究中，通过蔗糖摄入和高架十字迷宫试验评估了雄性小鼠暴露于大鼠感官刺激的影响。在蔗糖摄入任务（预应力阶段）中训练CDI雄性小鼠，随后将其分配到两组中。应激组与大鼠同处一室，对照组与小鼠同处一室（应激阶段）。转移后，对动物进行蔗糖摄入量和十字迷宫测试（急性测试），并每周重新测试三次蔗糖摄入量，并在最后一天在十字迷宫中重新测试一次（慢性测试）。在急性暴露于捕食者后，应激和对照动物之间的唯一区别是前者在十字迷宫上留下的粪便boli数量更多。在慢性阶段，应激动物表现出较低水平的蔗糖摄入量和较高水平的焦虑比对照组。总之，这项研究表明，长期暴露的雄性小鼠刺激大鼠降低了敏感性的奖励性质的蔗糖，并防止在对照组中观察到的加迷宫的习惯。因此，这项研究表明，小鼠暴露于大鼠的感官刺激可能会提供一个动物模型的压力，这些物种不应该被常规圈养在一起。(C)1999 Elsevier Science Inc.
In this study, the effect of the exposure of male mice to sensory stimuli from rats was assessed on both sucrose intake and the elevated plus-maze tests. CDI male mice were trained in the sucrose intake task (the prestress phase) and, subsequently, distributed into two groups. The stressed group was accommodated in the same room as rats and the control group with mice (the stress phase). After being transferred, animals were tested on sucrose intake and the plus-maze (acute tests) and retested three times a week for sucrose intake and once on plus-maze on the last day (chronic tests). After acute exposure to the predator, the only difference between stressed and control animals was a higher number of fecal boli left on the plus-maze by the former. During the chronic phase, stressed animals showed a lower level of sucrose intake and higher level of anxiety than controls. In conclusion, this study shows that chronic exposure of male mice to stimuli from rats reduces the sensitivity to the rewarding properties of sucrose and prevents the habituation to the plus-maze observed in controls. Thus, this study suggests that exposure of mice to sensory stimuli from rats may provide an animal model of stress, and that these species should not be routinely housed together. (C) 1999 Elsevier Science Inc.