The AIDS and Cancer Specimen Resource: role in HIV/AIDS scientific discovery.
The AIDS and Cancer Specimen Resource: role in HIV/AIDS scientific discovery.
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DOI：
10.1186/1750-9378-2-7
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发表时间：
2007-03-02
影响因子：
3.7
通讯作者：
Orenstein, Jan M
中科院分区：
文献类型：
--
作者：
Ayers, Leona W;Silver, Sylvia;Orenstein, Jan M
艾滋病癌症和标本资源 (ACSR) 支持艾滋病毒/艾滋病相关恶性肿瘤领域的科学发现。 ACSR 是 NCI（癌症治疗和诊断司主任办公室）与地区联盟、加州大学旧金山分校（西海岸）、乔治华盛顿大学（东海岸）和俄亥俄州立大学（中部地区）之间的一项合作协议，旨在收集、保存和分发 HIV 相关组织、生物液体和对照以及临床数据给合格的研究人员。 ACSR 网站上描述了具有临床数据的可用生物样本和应用程序。 ACSR 组织库拥有超过 100,000 份人类 HIV 阳性标本，代表不同的处理 (43)、标本 (15) 和解剖部位 (50) 类型。 ACSR 提供特殊的生物样本收藏并准备专业项目，例如组织微阵列 (TMA)、DNA 文库。卡波西肉瘤 (32%) 和非霍奇金淋巴瘤 (26%) 的需求量最大。分散的请求包括 83% 的组织（冷冻和石蜡包埋）、18% 的血浆/血清和 9% 的其他。 ACSR 还提供卡波西肉瘤和非霍奇金淋巴瘤等组织微阵列，用于生物标志物检测，并与其他团体开展合作，提供更多与艾滋病相关的恶性肿瘤样本。 ACSR 成员和同事已完成 63 次讲台和海报展示。调查人员已提交 125 份意向书请求。使用 ACSR 的发现已在 61 份著名期刊的科学出版物中报道，平均影响因子为 7。ACSR 通过参加国家和国际科学会议、与在该领域进行富有成效研究的研究人员联系以及免费识别、收集、保存、增强和分发 HIV/AIDS 相关恶性肿瘤标本来促进对 HIV/AIDS 与恶性肿瘤之间关系的科学探索。这个独特的生物样本库推动了科学发现。鼓励研究人员浏览 ACSR 互联网站点以获取材料，以增强他们自己的科学主动性。
The AIDS Cancer and Specimen Resource (ACSR) supports scientific discovery in the area of HIV/AIDS-associated malignancies. The ACSR was established as a cooperative agreement between the NCI (Office of the Director, Division of Cancer Treatment and Diagnosis) and regional consortia, University of California, San Francisco (West Coast), George Washington University (East Coast) and Ohio State University (Mid-Region) to collect, preserve and disperse HIV-related tissues and biologic fluids and controls along with clinical data to qualified investigators. The available biological samples with clinical data and the application process are described on the ACSR web site. The ACSR tissue bank has more than 100,000 human HIV positive specimens that represent different processing (43), specimen (15), and anatomical site (50) types. The ACSR provides special biospecimen collections and prepares speciality items, e.g., tissue microarrays (TMA), DNA libraries. Requests have been greatest for Kaposi's sarcoma (32%) and non-Hodgkin's lymphoma (26%). Dispersed requests include 83% tissue (frozen and paraffin embedded), 18% plasma/serum and 9% other. ACSR also provides tissue microarrays of, e.g., Kaposi's sarcoma and non-Hodgkin's lymphoma, for biomarker assays and has developed collaborations with other groups that provide access to additional AIDS-related malignancy specimens. ACSR members and associates have completed 63 podium and poster presentations. Investigators have submitted 125 letters of intent requests. Discoveries using ACSR have been reported in 61 scientific publications in notable journals with an average impact factor of 7. The ACSR promotes the scientific exploration of the relationship between HIV/AIDS and malignancy by participation at national and international scientific meetings, contact with investigators who have productive research in this area and identifying, collecting, preserving, enhancing, and dispersing HIV/AIDS-related malignancy specimens to funded, approved researchers at no fee. Scientific discovery has been advanced by this unique biorepository. Investigators are encouraged to browse the ACSR Internet site for materials to enhance their own scientific initiatives.