Increased erythrocyte protoporphyrins and blood lead--a pilot study of childhood growth patterns.
Increased erythrocyte protoporphyrins and blood lead--a pilot study of childhood growth patterns.
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红细胞原卟啉和血铅增加——儿童生长模式的初步研究。
DOI：
10.1080/15287398909531241
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Kuntzelman,DR
中科院分区：
文献类型：
--
作者：
Angle,CR;Kuntzelman,DR
1976-1980 年国家健康与营养调查表明，2680 名 1-7 岁儿童的血铅水平为 8-35 μg/dl (0.4-1.7 μM) 与身高和体重呈负相关。尚未检查生长情况。对 54 名儿童进行了一项回顾性初步研究，研究对象为 0-42 个月时的生长情况，发现 12-23 个月时红细胞原卟啉>35 μg/dl (0.6 mM)。对于 24/54，所有血铅均 < 30 μg/dl (1.2 μM)，年峰值平均值为 18.5 μg/dl (0.9 μM)；对于 30/54，12-23 个月时的平均血铅为 46.7 μg/dl (2.2 μM)，随后所有血铅≥30 μg/dl (1.2 μM)。两组的出生时平均身高和体重均位于第 25 个百分位数。高铅儿童在 15 个月时体重速度增加，并在 24 个月时体重增加。体重增加与总热量摄入、辅助食物消耗和手-口行为有关，是 9-24 个月龄血铅增加的重要因素。然而，24 个月后身高和体重百分位的每月方向变化显示，当血铅≥30 μg/dl 时，向上移动的频率降低。尽管早期高食物摄入量似乎会增加食物和口腔中铅的摄入量，从而导致高血铅，但高血铅和红细胞原卟啉的持续增加与随后的生长迟缓有关。
The National Health and Nutrition Survey 1976–1980 demonstrated the inverse association of blood lead 8–35 μg/dl (0.4–1.7 μM) with height and weight in 2680 children 1–7 yr old. Growth has not been examined. A retrospective pilot study was made of growth, 0–42 mo, for 54 children found to have erythrocyte protoporphyrins >35 μg/dl (0.6 mM) at 12–23 mo. For 24/54, all blood leads were < 30 μg/dl (1.2 μM), with a peak annual mean of 18.5 μg/dl (0.9 μM); for 30/54, mean blood lead was 46.7 μg/dl (2.2 μM) at 12–23 mo with all subsequent blood leads ≥30 μg/dl (1.2 μM). In both groups the mean height and weight at birth were at the 25th percentile. The high‐lead children had increased weight velocity at 15 mo of age and were heavier at 24 mo. Weight gain related to total caloric intake, supporting food consumption, and hand‐to‐mouth behavior as significant factors in an increased blood lead ages 9–24 mo. The monthly directional change of height and weight percentiles after 24 mo, however, showed a decreased frequency of upward shifts when blood lead was ≥30 μg/dl. Although an early high food intake appears to contribute to high blood lead by increasing the intake of lead from food and mouthing, persistent increases in the high blood lead and erythrocyte protoporphyrins were associated with subsequent growth retardation.