QUANTITATION IN POSITRON EMISSION COMPUTED-TOMOGRAPHY .1. EFFECT OF OBJECT SIZE
QUANTITATION IN POSITRON EMISSION COMPUTED-TOMOGRAPHY .1. EFFECT OF OBJECT SIZE
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DOI：
10.1097/00004728-197906000-00001
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发表时间：
1979-01-01
影响因子：
1.3
通讯作者：
PHELPS, ME
中科院分区：
文献类型：
--
作者：
HOFFMAN, EJ;HUANG, SC;PHELPS, ME
研究了物体尺寸对正电子发射计算机断层扫描测量截面中同位素浓度的能力的影响。在3种仪器分辨率和4种卷积滤波器下，测量图像中的表观同位素浓度与真实浓度之间的关系，作为对象大小的函数。在相同的条件下，也测量了图像尺寸和物体尺寸之间的关系。凹陷的表观同位素浓度的图像中的对象的大小等于仪器分辨率（FWHM）是显着的（50%的圆柱体和25%的酒吧）。对于大于1.0 FWHM的对象，可以从图像中估计准确的对象大小。因此，对于大于1.0 FWHM的物体，可以实现对物体尺寸效应的补偿的合理准确和实用的方案。在较小的对象中定量同位素浓度的准确性受到严重损害的对象大小的灵敏度和补偿仪器响应所需的大的校正因子的损失。测量的结果与理论预测的理想系统的可比分辨率。
The effect of object size on the capability of positron emission computed tomography to measure isotope concentrations in a cross section was studied. The relationship between the apparent isotope concentration in an image and the true concentration was measured as a function of object size for 3 instrument resolutions and 4 convolution filters. The relationship between image size and object size was also measured under the same conditions. Depression of apparent isotope concentration in an image for objects equal in size to the instrument resolution (FWHM) was significant (50% for a cylinder and 25% for a bar). For objects larger than 1.0 FWHM, accurate object sizes can be estimated from the images. Thus, reasonably accurate and practical schemes of compensation for object size effects can be implemented for objects larger than 1.0 FWHM. Accuracy in quantitating isotope concentrations in smaller objects is seriously compromised by the loss of sensitivity to the object size and the large correction factors required to compensate for instrument response. The results of the measurements were in good agreement with theoretical predictions for ideal systems of comparable resolution.