Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-(4-(5-Nitro-2-furyl)-2-thiazolyl)formamide.
Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-(4-(5-Nitro-2-furyl)-2-thiazolyl)formamide.
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维生素A缺乏症和维生素A过多症对N-(4-(5-硝基-2-呋喃基)-2-噻唑基)甲酰胺膀胱致癌性的影响。
作者：
S. Cohen;J. Wittenberg;G. Bryan
在雌性断奶 Sprague-Dawley 大鼠中测定了维生素 A 缺乏和维生素 A 过多对 N-[4-(5-硝基-2-呋喃基)-2-噻唑基]甲酰胺 (FANFT) 尿路上皮致癌性的影响。维生素A缺乏导致膀胱鳞状化生，膀胱炎、输尿管炎、肾盂肾炎的发病率高。对维生素 A 缺乏的大鼠施用 FANFT 似乎会加速致癌过程，使膀胱肿瘤更早出现以及输尿管癌和肾盂癌的发展。这些肿瘤大多数为鳞状细胞，偶尔有移行细胞灶。维生素 A 过多可预防喂食 FANFT 的大鼠出现鳞状化生和鳞状细胞瘤形成，但与接受正常水平维生素 A 和 FANFT 的大鼠相比，它不能抑制移行细胞增生或瘤形成的形成。
The effect of vitamin A deficiency and hypervitaminosis A on the urothelial carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formanmide (FANFT) was determined in female weanling Sprague-Dawley rats. Vitamin A deficiency resulted in squamous metaplasia of the urinary bladder and high incidences of cystitis, ureteritis, and pyelonephritis. Administration of FANFT to vitamin A-deficient rats appeared to accelerate the carcinogenic process, with earlier appearance of urinary bladder tumors and the development of ureteral and renal pelvic carcinomas. Most of these tumors were squamous cell, occasionally with transitional cell foci. Hypervitaminosis A prevented the appearance of squamous metaplasia and squamous cell neoplasia in rats fed FANFT, but it did not inhibit the formation of transitional cell hyperplasia or neoplasia in comparison to rats receiving normal levels of vitamin A and FANFT.