Differences in spirometry reference values: a statistical comparison of a Mongolian and a Caucasian study
Differences in spirometry reference values: a statistical comparison of a Mongolian and a Caucasian study
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DOI：
10.1183/09031936.99.13360699
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发表时间：
1999-03-01
影响因子：
24.3
通讯作者：
Schmidt, CD
中科院分区：
文献类型：
--
作者：
Crapo, RO;Jensen, RL;Schmidt, CD
肺量测定法的新参考值研究通常使用从现有参考方程导出的平均数据与现有参考值研究进行比较。这种比较本质上是有缺陷的，因为它们没有考虑到独立变量和因变量分布的差异，而且它们没有相同的方法。本研究的目的是：1）推导蒙古族人用力肺活量（FVC）和一秒用力呼气量（FEV 1）的参考方程; 2）将蒙古族数据与1981年美国犹他州湖城白人参考研究的数据进行比较。（176名男性，168名女性）健康、不吸烟的蒙古城市本地人，以生成FVC、FEV 1和FEV 1/FVC的参考方程，这些数据与1981年湖城白人参考研究的数据进行了比较，使用原始数据的协方差分析，参数和非参数的匹配对子集的比较。平均测得的用力肺活量和用力呼气量在一秒钟内在本地蒙古人的高加索人预测值的1-2%。这些微小差异在多种比较方法中均无统计学显著性。功效分析表明，如果存在真实的差异，则用力肺活量的差异为
New reference value studies for spirometry are commonly compared to existing reference value studies using average data derived from existing reference equations. Such comparisons are inherently flawed because they do not account for differences in distributions of the independent and dependent variables and they do not have identical methodologies. This study was undertaken 1) to derive reference equations for forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) for natives of Mongolia and 2) to compare the Mongolian data with data from a 1981 reference study of Caucasians in Salt Lake City, UT, USA.Spirometry was performed on 344 (176 male, 168 female) healthy, nonsmoking urban natives of Mongolia to generate reference equations for FVC, FEV1, and FEV1/FVC, These data were compared with data from a 1981 reference study of Caucasians in Salt Lake City using both an analysis of covariance of the raw data and parametric and nonparametric comparisons of a matched pair subset.Average measured forced vital capacity and forced expiratory volume in one second in native Mongolians were within 1-2% of the Caucasian predicted values. These small differences are not statistically significant in any of the multiple methods of comparisons. Power analysis suggests that, if real differences exist, the differences in forced vital capacity are