Thinking Soils: A synthetic biology approach to material-based design computation
Thinking Soils: A synthetic biology approach to material-based design computation
复制标题
思考土壤：基于材料的设计计算的合成生物学方法
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Luis Hernan
中科院分区：
文献类型：
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作者：
M. Dade;J. Corral;Helen Mitrani;Meng Zhang;A. Wipat;Carolina Ramirez;Luis Hernan
本文详细介绍了基于基因工程细菌细胞的新型响应材料系统的计算建模工作。我们介绍了合成生物学的学科，并展示了如何可能编程细胞对环境的输入做出遗传反应。我们提出了一个系统的合成biocementing，其中工程细胞，生活在土壤基质中，响应孔隙压力的变化，在他们的环境中，当土壤加载合成新材料和加强土壤。我们开发了一个原型CAD系统，映射单个细菌细胞的遗传反应的应力和孔隙压力的岩土模型。我们发现不同的基因启动子敏感性可能会使巩固模式发生实质性变化。最后，我们指出未来的研究在这一领域结合在体内和在硅片上的工作。
The paper details the computational modelling work to define a new type of responsive material system based on genetically engineered bacteria cells. We introduce the discipline of synthetic biology and show how it may be possible to program a cell to respond genetically to inputs from its environment. We propose a system of synthetic biocementing, where engineered cells, living within a soil matrix, respond to pore pressure changes in their environment when the soil is loaded by synthesising new material and strengthening the soil. We develop a prototype CAD system which maps genetic responses of individual bacteria cells to geotechnical models of stress and pore pressure. We show different gene promoter sensitivities may make substantial changes to patterns of consolidation. We conclude by indicating future research in this area which combines both in vivo and in silico work.