Absence of association between mannose-binding lectin gene polymorphisms and HIV-1 infection in a Colombian population
Absence of association between mannose-binding lectin gene polymorphisms and HIV-1 infection in a Colombian population
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DOI：
10.1007/s00251-003-0550-4
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发表时间：
2003-04-01
期刊：
影响因子：
3.2
通讯作者：
Schurr, E
中科院分区：
文献类型：
--
作者：
Malik, S;Arias, M;Schurr, E
甘露糖结合凝集素（MBL）是一种钙依赖性凝集素，通过激活经典补体途径和吞噬作用，在感染的先天免疫中发挥重要作用。体外研究表明MBL能够与gp120 HIV-1表面抗原结合，并且该基因的变异与斯堪的纳维亚人感染HIV的风险增加有关。我们调查了278名哥伦比亚hiv感染者和对照个体的遗传MBL变异与HIV-1感染的关系。两组MBL基因型频率相似，MBL等位基因B、C和D与HIV-1感染易感性之间无相关性（P=1.0）。由于在检测的MBL等位基因和非常低的MBL血清浓度之间有充分的证据证明存在联系，因此这些结果不支持MBL水平是哥伦比亚HIV-1感染危险因素的假设。
Mannose-binding lectin (MBL) is a calcium-dependent lectin shown to play an important role in innate immunity to infection by activating the classical complement pathway and phagocytosis. In vitro studies have shown that MBL is able to bind to the gp120 HIV-1 surface antigen, and variants of the gene are associated with increased risk of HIV infection among Scandinavians. We investigated the association of genetic MBL variants and HIV-1 infection in 278 Colombian HIV-infected and control individuals. MBL genotype frequencies were similar for both groups, and no association was detected between MBL alleles B, C, and D and susceptibility to HIV-1 infection (P=1.0). Since there is a well-documented link between the tested MBL alleles and very low MBL serum concentration, these results do not support the hypothesis that MBL levels are a risk factor for HIV-1 infection in Colombia.