Spread of methicillin-resistant Staphylococcus aureus (MRSA) among household contacts of individuals with nosocomially acquired MRSA
Spread of methicillin-resistant Staphylococcus aureus (MRSA) among household contacts of individuals with nosocomially acquired MRSA
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DOI：
10.1086/502225
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发表时间：
2003-06-01
影响因子：
4.5
通讯作者：
Farr, BM
中科院分区：
文献类型：
--
作者：
Calfee, DP;Durbin, LJ;Farr, BM
目的：确定耐甲氧西林金黄色葡萄球菌（MRSA）从定殖或感染患者向其家庭和社区接触者传播的频率。设计：回顾性队列研究。单位：大学医院。参与者：进行MRSA筛选培养的MRSA定殖或感染患者的家庭和社区接触者。结果：172例患者中分离到MRSA 25例（14.5%）。在至少有一次mrsa定殖接触者中，与指数患者密切接触者被定殖的可能性是指数患者的7.5倍（53% vs 7%； 95%可信区间为1.1 ~ 50.3;P = 0.002）。抗菌药物敏感性和DNA指纹图谱分析表明该病毒是人际传播的。结论：MRSA定植经常发生在医院获得性MRSA患者的家庭和社区接触者中，提示医院获得性MRSA在医疗机构外的传播可能是MRSA定植和社区感染的重要来源。
OBJECTIVE: To determine the frequency with which methicillin-resistant Staphylococcus aureus (MRSA) is spread from colonized or infected patients to their household and community contacts.DESIGN: Retrospective cohort study.SETTING: University hospital.PARTICIPANTS: Household and community contacts of MRSA-colonized or -infected patients for whom MRSA screening cultures were performed.RESULTS: MRSA was isolated from 25 (14.5%) of 172 individuals. Among the contacts of index patients who had at least one MRSA-colonized contact, those with close contact to the index patient were 7.5 times more likely to be colonized (53% vs 7%; 95% confidence interval, 1.1 to 50.3; P =.002). An analysis of antimicrobial susceptibility and DNA fingerprint patterns suggested person-to-person spread.CONCLUSIONS: MRSA colonization occurs frequently among household and community contacts of patients with nosocomially acquired MRSA, suggesting that transmission of nosocomially acquired MRSA outside of the healthcare setting may be a substantial source of MRSA colonization and infection in the community.