A TRANSMISSION ELECTRON-MICROSCOPIC STUDY ON SINUSOIDAL CELLS OF GUINEA-PIG LIVER, WITH SPECIAL REFERENCE TO THE OCCURRENCE OF A CANALICULAR SYSTEM AND PORED DOMES IN THE ENDOTHELIUM
A TRANSMISSION ELECTRON-MICROSCOPIC STUDY ON SINUSOIDAL CELLS OF GUINEA-PIG LIVER, WITH SPECIAL REFERENCE TO THE OCCURRENCE OF A CANALICULAR SYSTEM AND PORED DOMES IN THE ENDOTHELIUM
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DOI：
10.1679/aohc.47.359
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
ITO, T
中科院分区：
文献类型：
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作者：
OHATA, M;TANUMA, Y;ITO, T
用透射电镜观察了豚鼠肝窦细胞。一个曲折的小管系统中检测到窦内皮细胞在较厚的部分细胞质的延伸和小面积的核周。它由具有空泡扩张和收缩的弯曲小管组成，这些小管穿过内皮细胞质，形成一个整体网络。泪小管有2个以上的开口，常与窦状隙相通，但偶尔汇入Disse间隙。这种小管网络似乎允许血浆渗透。在豚鼠肝窦内皮细胞核周细胞质上也可见大鼠和家兔肾小球内皮细胞上的“多孔细胞”。在窦内皮细胞内发现了变黑的脂滴，提示有脂质释放到窦内。短期给予过量维生素A对内皮脂滴无影响。豚鼠是一种啮齿类动物，其贮脂细胞中储存极少量的脂滴，并且经常检测到所谓的空贮脂细胞。与其他物种一样，在豚鼠的脂肪储存细胞中经常发现单个纤毛。
Hepatic sinusoidal cells in the guinea-pig were examined by transmission electron microscopy. A meandering canalicular system was detected in the sinusoidal endothelial cell both in thicker portions of cytoplasmic extensions and in small areas of the perikaryon. It consisted of meandering canaliculi with vacuolar expansions and constrictions, which penetrated the endothelial cytoplasm, forming as a whole a network. The canaliculi possessed more than 2 openings which usually communicated with the sinusoid, but occasionally poured themselves into the Disse''s space. This network of canaliculi seems to permit infiltration of blood plasma. The ''''pored domes'''' on the glomerular endothelium of the rat and rabbit kidney were also revealed on the perikaryonal cytoplasm of the sinusoidal endothelium of guinea pig liver. Os-blackened lipid droplets were found in the sinusoidal endothelium, which suggested the release of lipid into the sinusoid. Short-term administrations of excessive vitamn A exerted no influence on the endothelial lipid droplets. The guinea-pig is a rodent species which stores a very small amount of lipid droplets in its fat-storing cells and the so-called empty fat-storing cells were frequently detected. A single cilium was often found in the fat-storing cells in the guinea-pig as in other species.