A Potential Peptide Pathway From Viruses to Oral Lichen Planus
A Potential Peptide Pathway From Viruses to Oral Lichen Planus
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DOI：
10.1002/jmv.24131
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发表时间：
2015-06-01
影响因子：
12.7
通讯作者：
Lucchese, Alberta
中科院分区：
文献类型：
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作者：
Lucchese, Alberta
口腔扁平苔藓是一种特发性口腔粘膜炎性疾病，其特征是T细胞对自身免疫性表皮的攻击。然而，这种攻击性T细胞如何在体内被激活以引起表皮损伤仍然是未知的。本研究从多肽水平分析病毒与口腔扁平苔藓的关系。发现HCV、EBV、HHV-7、HSV-1和CMV与三种人蛋白质（即松蛋白、桥粒芯糖蛋白-3和plectin）共享四种潜在免疫原性肽（SSSSSSS、QEQLEKA、LLLLLLA和MLSGNAG）。所描述的肽共享可能有助于破译仍然无法解释的导致口腔扁平苔藓的免疫致病途径。J. Med. Virol. 87：1060 - 1065，2015. (c)2015年威利期刊公司
Oral lichen planus is an idiopathic inflammatory disease of oral mucous membranes, characterized by an autoimmune epidermis attack by T cells. It remains unknown, however, how such aggressive T cells are activated in vivo to cause epidermal damage. This study analyzes the relationship at the peptide level between viruses and oral lichen planus disease. Four potentially immunogenic peptides (SSSSSSS, QEQLEKA, LLLLLLA, and MLSGNAG) are found to be shared between HCV, EBV, HHV-7, HSV-1, and CMV and three human proteins (namely pinin, desmoglein-3, and plectin). The described peptide sharing might be of help in deciphering the still unexplained immunopathogenic pathway that leads to oral lichen planus. J. Med. Virol. 87:1060-1065, 2015. (c) 2015 Wiley Periodicals, Inc.