The differential relationship between cocaine use and marijuana use on decision-making performance over repeat testing with the Iowa Gambling Task
The differential relationship between cocaine use and marijuana use on decision-making performance over repeat testing with the Iowa Gambling Task
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DOI：
10.1016/j.drugalcdep.2007.02.004
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发表时间：
2007-09-06
影响因子：
4.2
通讯作者：
Bolla, Karen I.
中科院分区：
文献类型：
--
作者：
Verdejo-Garcia, Antonio;Benbrook, Amy;Bolla, Karen I.
决策缺陷与药物滥用有很强的认知相关性，但很少有研究探讨可卡因使用和大麻 (MJ) 使用对决策的长期差异关联。本研究利用爱荷华州赌博任务 (IGT)（一种广泛使用的决策衡量标准）来调查可卡因、MJ 使用和 IGT 学习之间的关系。我们分析了对零或可卡因戒断使用者连续两次测试的组间和组内差异。我们通过评估强制戒酒 25 天后的使用者来评估这些药物使用的长期相关性。结果显示，可卡因使用者和 MJ 使用者在 IGT 总净得分上的表现都比对照组差。所有组在第 1 节和第 2 节之间都表现出学习效果，但可卡因使用者的表现增幅最小。药物组从 IGT（第 2 节）开始到结束（块 x 块）的学习模式有所不同，可卡因组比 MJ 组表现出更多的学习效果。可卡因使用（克/周）和 MJ 使用（关节/周）的剂量相关测量可预测 IGT 表现（吸毒越重，表现越低）。可卡因使用和 MJ 使用对决策学习的差异相关性可能对新型治疗干预措施的开发具有重要意义。 (c) 2007 Elsevier Ireland Ltd. 保留所有权利。
Decision-making deficits area robust cognitive correlate of substance abuse, but few studies have addressed the long-term differential associations of cocaine use and marijuana (MJ) use on decision-making. This study utilized the Iowa Gambling Task (IGT), a widely used measure of decision-making, to investigate the relationship between cocaine and MJ use and IGT learning. We analyzed between and within group differences across two consecutive testing sessions in abstinent users of either Nil or cocaine. We assessed long-term correlates of the use of these drugs by evaluating users after 25 days of enforced abstinence. Results showed that both cocaine users and MJ users performed worse than controls on the total IGT net score. All groups showed learning between Session 1 and Session 2, but the cocaine users showed the smallest increase in performance. The pattern of learning from the beginning to the end (block x block) of the IGT (Session 2) was different for the drug groups, with the cocaine group showing more learning than the MJ group. Dose-related measures of cocaine use (g/week) and MJ use (joints/week) predicted IGT performance (the heavier the drug use the lower the performance). Differential correlates of cocaine use and MJ use on decision-making learning may have important implications for the development of novel treatment interventions. (c) 2007 Elsevier Ireland Ltd. All rights reserved.