A genome-wide copy number variant study of suicidal behavior.
A genome-wide copy number variant study of suicidal behavior.
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DOI：
10.1371/journal.pone.0128369
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Turecki G
中科院分区：
文献类型：
--
作者：
Gross JA;Bureau A;Croteau J;Galfalvy H;Oquendo MA;Haghighi F;Mérette C;Giegling I;Hodgkinson C;Goldman D;Rujescu D;Mann JJ;Turecki G
自杀和自杀未遂是由不同因素相互作用导致的复杂行为，其中包括增加自杀行为倾向的基因变异。拷贝数变异 (CNV) 是 DNA 片段的缺失或重复，通常大于 1 KB。这些结构性遗传变化虽然相当罕见，但与自闭症、精神分裂症和双相情感障碍等精神疾病的遗传倾向有关。目前尚未发表全基因组水平的研究来调查 CNV 在自杀行为中的潜在作用。基于单核苷酸多态性芯片数据，我们按照 Penn-CNV 标准检测了 1,608 名受试者的 CNV，其中包括 475 名自杀和自杀未遂病例以及 1,133 名对照者。尽管最初的算法分别确定了 7 例和 8 例病例中 6 号染色体和 12 号染色体上存在 CNV，但与对照组相比均无，但对原始数据的目视检查并不支持这一发现。此外，我们无法通过 CNV 特异性实时聚合酶链反应验证这些发现。此外，罕见 CNV 负担分析并未发现我们样本人群中罕见 CNV 的频率或长度与自杀行为之间存在关联。尽管我们的研究结果表明CNV在自杀行为的病因学中并不发挥重要作用，但它们与文献中的有力证据并不矛盾，这些证据表明其他遗传变异解释了自杀行为总表型变异的一部分。
Suicide and suicide attempts are complex behaviors that result from the interaction of different factors, including genetic variants that increase the predisposition to suicidal behaviors. Copy number variations (CNVs) are deletions or duplications of a segment of DNA usually larger than one kilobase. These structural genetic changes, although quite rare, have been associated with genetic liability to mental disorders, such as autism, schizophrenia, and bipolar disorder. No genome-wide level studies have been published investigating the potential role of CNVs in suicidal behaviors. Based on single-nucleotide polymorphism array data, we followed the Penn-CNV standards to detect CNVs in 1,608 subjects, comprising 475 suicide and suicide attempt cases and 1,133 controls. Although the initial algorithms determined the presence of CNVs on chromosomes 6 and 12 in seven and eight cases, respectively, compared with none of the controls, visual inspection of the raw data did not support this finding. Furthermore we were unable to validate these findings by CNV-specific real-time polymerase chain reaction. Additionally, rare CNV burden analysis did not find an association between the frequency or length of rare CNVs and suicidal behavior in our sample population. Although our findings suggest CNVs do not play an important role in the etiology of suicidal behaviors, they are not inconsistent with the strong evidence from the literature suggesting that other genetic variants account for a portion of the total phenotypic variability in suicidal behavior.
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影响因子：
16.2
作者：
Malhotra D;McCarthy S;Michaelson JJ;Vacic V;Burdick KE;Yoon S;Cichon S;Corvin A;Gary S;Gershon ES;Gill M;Karayiorgou M;Kelsoe JR;Krastoshevsky O;Krause V;Leibenluft E;Levy DL;Makarov V;Bhandari A;Malhotra AK;McMahon FJ;Nöthen MM;Potash JB;Rietschel M;Schulze TG;Sebat J
通讯作者：
Sebat J
影响因子：
64.5
作者：
Martin I;Kim JW;Lee BD;Kang HC;Xu JC;Jia H;Stankowski J;Kim MS;Zhong J;Kumar M;Andrabi SA;Xiong Y;Dickson DW;Wszolek ZK;Pandey A;Dawson TM;Dawson VL
通讯作者：
Dawson VL
影响因子：
5.5
作者：
Li, Hong-Lei;Lu, Shen-Ji;Wu, Zhi-Ying
通讯作者：
Wu, Zhi-Ying
影响因子：
11
作者：
通讯作者：
--
DOI：
10.14482/psdc.36.1.378.2
发表时间：
2019-04-01
期刊：
Psicología desde el Caribe
影响因子：
--
作者：
Reynoso González, Oscar Ulises;Caldera Montes, Juan Francisco;Velázquez Aceves, Luz Adriana
通讯作者：
Velázquez Aceves, Luz Adriana