Gene-based therapy of malignant melanoma.
Gene-based therapy of malignant melanoma.
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恶性黑色素瘤的基因治疗。
DOI：
10.1053/sonc.2002.35245
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发表时间：
2002
影响因子：
4
通讯作者：
D. Schadendorf
中科院分区：
文献类型：
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作者：
D. Schadendorf
黑色素瘤仍然是肿瘤学家、肿瘤外科医生和皮肤科医生面临的主要治疗挑战。分子遗传学的最新进展和我们对肿瘤免疫反应的理解的改善已经产生了使用基于基因的治疗策略来对抗黑色素瘤的兴趣。已经出现了几种基本策略：（1）通过使用免疫刺激基因如细胞因子对宿主的一些靶细胞群体进行遗传修饰以及通过用编码由细胞毒性T细胞识别的黑素瘤相关抗原的基因进行遗传免疫来增强针对肿瘤的免疫应答;（2）干扰信号传导级联;以及（3）自杀基因策略。本文回顾了这些新的策略，并总结了欧洲团体在实验研究或临床试验中产生的最新数据。
Melanoma continues to present a major therapeutic challenge to oncologists, oncologic surgeons, and dermatologists. Recent advances in molecular genetics and improvement in our understanding of immune responses to tumors have generated an interest in using gene-based treatment strategies to fight melanoma. Several basic strategies have emerged: (1) strengthening of the immune response against tumors by genetic modification of some target cell populations of the host using immunostimulatory genes such as cytokines and by genetic immunization with the genes coding for melanoma-associated antigens recognized by cytotoxic T cells; (2) interference with signaling cascades; and (3) suicide gene strategies. This article reviews these novel strategies and summarizes the most recent data generated by European groups either in experimental studies or in clinical trials.