Esophageal cancer: Cases and causes (Part I)
Esophageal cancer: Cases and causes (Part I)
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DOI：
10.1055/s-2007-966530
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发表时间：
2007-06-01
期刊：
影响因子：
9.3
通讯作者：
Hainaut, P.
中科院分区：
文献类型：
--
作者：
Lambert, R.;Hainaut, P.
据估计，2002年全世界食管癌（男女）负担为46.2万新病例和38.6万例死亡；死亡率与发病率的高比率（0.83）证实预后较差。亚洲国家负担最重，每年新增病例36.2万例，死亡29.3万例。使用年龄标准化率（ASR），估计全世界男性发病率为每10万人11.5例，女性发病率为每10万人4.7例。在亚洲的某些地区，如中国的慈县（见表1）和非洲，发病率要高得多。大多数病例为鳞状细胞癌（SCC）；Barrett食管腺癌（ADC）的发病率在一些资源丰富的国家呈上升趋势，但发病率较低。在未确定病例比例较小的登记处中发现可靠的组织学数据（“表2”和“表3”）。食管胃交界处的肿瘤常被误诊为食管远端或贲门。
The worldwide burden of esophageal cancer (for both sexes) was estimated in 2002 [1] as 462000 new cases and 386000 deaths; the high ratio (0.83) of mortality to incidence confirms a poor prognosis. Asiatic countries share most of the burden with 362000 new cases annually and 293000 deaths. Using an age-standardized rate (ASR), incidence is estimated worldwide at 11.5 per 100 000 in men and 4.7 per 100000 in women. Much higher rates occur in certain regions of Asia, such as Cixian in China (●" Table 1), and of Africa [2].Most cases are squamous cell carcinomas (SCC); adenocarcinoma (ADC) in Barrett esophagus is less frequent, although its incidence is on the rise in several high-resource countries. Reliable data on histology are found in registries in which the proportion of unspecified cases is small (●" Tables 2 and●" 3). Tumors at the esophagogastric junction are often misclassified between the distal esophagus or the gastric cardia.