Oral transmission of human T-cell leukemia virus type-I into a common marmoset (Callithrix jacchus) as an experimental model for milk-borne transmission.
Oral transmission of human T-cell leukemia virus type-I into a common marmoset (Callithrix jacchus) as an experimental model for milk-borne transmission.
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人类 T 细胞白血病病毒 I 型经口传播到普通狨猴（Callithrix jacchus）中，作为乳源传播的实验模型。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
S. Hino
中科院分区：
文献类型：
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作者：
K. Yamanouchi;K. Kinoshita;R. Moriuchi;S. Katamine;T. Amagasaki;S. Ikeda;M. Ichimaru;T. Miyamoto;S. Hino
为了获得人类t细胞白血病病毒i型（HTLV-I）可能的乳源性感染的实验支持，从成人t细胞白血病淋巴瘤复复症（ATLL）患者的外周血中获得的短期培养的病毒抗原阳性淋巴细胞接种到两只成年普通狨猴（Callithrix jacchus）的口腔中，其数量与用血清阳性母亲的乳汁喂养婴儿的HTLV-I携带细胞的数量相当。其中一只动物在第一次接种2.5个月后血清转化。绒猴外周血单核白细胞培养显示HTLV-I抗原在细胞中表达，表明HTLV-I在成年绒猴口腔感染的建立。推断导致感染的细胞数为5.6 X 10(7)个细胞（用于前2次接种）。结果表明，HTLV-I从血清阳性母亲传给孩子的概念是合理的。
To obtain experimental support for possible milk-borne infection of human T-cell leukemia virus type-I (HTLV-I), short-term-cultured viral antigen-positive lymphocytes obtained from peripheral blood of adult T-cell leukemia lymphoma complex (ATLL) patients were inoculated into the oral cavity of two adult common marmosets (Callithrix jacchus) in amounts comparable to those of HTLV-I-carrying cells fed to a baby in the milk of seropositive mothers. One of the animals seroconverted 2.5 months after the first inoculation. Cultures of peripheral blood mononuclear leukocytes of the marmoset revealed HTLV-I antigen expression in cells, indicating the establishment of oral infection of HTLV-I in an adult marmoset. The cell number deduced to be responsible for the infection was 5.6 X 10(7) cells (used in the first 2 inoculations). The results suggest that the concept of milk-borne infection of HTLV-I from a seropositive mother to her child is plausible.