Anal Sexually Transmitted Infections and Risk of HIV Infection in Homosexual Men
Anal Sexually Transmitted Infections and Risk of HIV Infection in Homosexual Men
复制标题
DOI：
10.1097/qai.0b013e3181b48f33
复制
发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Grulich, Andrew E.
中科院分区：
文献类型：
--
作者：
Jin, Fengyi;Prestage, Garrett P.;Grulich, Andrew E.
背景：我们在澳大利亚悉尼的艾滋病毒阴性同性恋男性社区队列中检查了一系列常见的细菌和病毒性传播感染作为艾滋病毒血清转化的危险因素。方法：通过每年两次的访谈收集有关艾滋病毒危险行为的详细信息。参与者每年接受艾滋病毒、肛门和尿道淋病、衣原体、1 型和 2 型单纯疱疹病毒以及梅毒检测。此外，他们还报告了这些病症以及生殖器疣和肛门疣的年度诊断结果。结果：在 1427 名登记参与者中，发现了 53 名 HIV 血清转化者，发病率为每 100 人年 0.78 人。在控制插入性和接受性非血清一致性无保护肛门性交的次数后，与肛门淋病（调整后的危险比 = 7.12，95% 置信区间：2.05 至 24.79）和肛门疣（风险比 = 3.63，95% 置信区间：1.62 至 8.14）存在独立关联。 结论： 肛门淋病和肛门疣与艾滋病毒感染独立相关。应考虑更频繁地进行肛门筛查，以便及早发现和治疗男同性恋者的肛门性传播感染，从而增加艾滋病毒预防价值。
Background: We examined a range of common bacterial and viral sexually transmitted infections as risk factors for HIV seroconversion in a community-based cohort of HIV-negative homosexual men in Sydney, Australia.Methods: Detailed information about HIV risk behaviors was collected by interview twice yearly. Participants were tested annually for HIV, anal and urethral gonorrhea and chlamydia, herpes simplex virus types 1 and 2, and syphilis. In addition, they reported annual diagnoses of these conditions and of genital and anal warts.Results: Among 1427 enrolled participants, 53 HIV seroconverters were identified, giving an incidence of 0.78 per 100 person-years. After controlling for number of episodes of insertive and receptive nonseroconcordant unprotected anal intercourse, there were independent associations with anal gonorrhea (adjusted hazard ratio = 7.12, 95% confidence interval: 2.05 to 24.79) and anal warts (hazard ratio = 3.63, 95% confidence interval: 1.62 to 8.14).Conclusions: Anal gonorrhea and anal warts were independently associated with HIV acquisition. The added HIV prevention value of more frequent screening of the anus to allow early detection and treatment of anal sexually transmitted infections in homosexual men should be considered.