The cellular and molecular basis of odor adaptation
The cellular and molecular basis of odor adaptation
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DOI：
10.1093/chemse/25.4.473
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发表时间：
2000-08-01
期刊：
影响因子：
3.5
通讯作者：
Leinders-Zufall, T
中科院分区：
文献类型：
--
作者：
Zufall, F;Leinders-Zufall, T
最近在理解气味适应方面的一个重要进展来自于发现气味适应的复杂机制已经发生在嗅觉系统的最早阶段，在嗅觉纤毛中。至少有两种快速形式和一种持久形式的气味适应共存于脊椎动物的嗅觉受体神经元。这三种不同的适应现象可以根据其不同的发病和恢复时间过程及其药理学特性进行剖析，表明它们至少部分地由单独的分子机制控制。证据提供了参与不同的分子步骤，这些形式的气味适应，包括通过环核苷酸门控（CNG）通道，Ca 2+依赖的CNG通道调制，Ca 2 +/钙调蛋白激酶II依赖衰减腺苷酸环化酶，和一氧化碳/环GMP第二信使系统的活性。这些分子步骤的鉴定可能有助于阐明嗅觉系统如何提取时间和强度信息，以及在何种程度上气味感知受到不同适应机制的影响。
An important recent advance in the understanding of odor adaptation has come from the discovery that complex mechanisms of odor adaptation already take place at the earliest stage of the olfactory system, in the olfactory cilia. At least two rapid forms and one persistent form of odor adaptation coexist in vertebrate olfactory receptor neurons. These three different adaptation phenomena can be dissected on the basis of their different onset and recovery time courses and their pharmacological properties, indicating that they are controlled, at least in part, by separate molecular mechanisms. Evidence is provided for the involvement of distinct molecular steps in these forms of odor adaptation, including Ca2+ entry through cyclic nucleotide-gated (CNG) channels, Ca2+-dependent CNG channel modulation, Ca2+/calmodulin kinase Ii-dependent attenuation of adenylyl cyclase, and the activity of the carbon monoxide/cyclic GMP second messenger system. Identification of these molecular steps may help to elucidate how the olfactory system extracts temporal and intensity information and to which extent odor perception is influenced by the different mechanisms underlying adaptation.