Tracing the genetic footprints of vertebrate landing in non-teleost ray-finned fishes
Tracing the genetic footprints of vertebrate landing in non-teleost ray-finned fishes
复制标题
追踪非硬骨鱼射线鳍鱼类的脊椎动物着陆的遗传足迹。
DOI：
10.1016/j.cell.2021.01.046
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发表时间：
2021-03-04
期刊：
影响因子：
64.5
通讯作者：
Zhang, Guojie
中科院分区：
文献类型：
--
作者：
Bi, Xupeng;Wang, Kun;Zhang, Guojie
丰富的化石证据表明，许多与陆地进化有关的特征和功能早在叶鳍鱼和辐鳍鱼的祖先之前就已经存在了。在这里，我们展示了bichir、白鲟、弓鳍鱼和鳄雀鳝的基因组序列，涵盖了辐鳍鱼的所有主要早期分歧谱系。我们的分析表明，这些物种表现出许多马赛克的叶鳍和射线鳍鱼类的基因组特征。特别是，许多肢体发育的调控元件存在于这些鱼类，支持的假设，即相关的祖先调控网络出现之前的四足动物的起源。转录组分析证实了肺和鱼鳔之间的同源性，并揭示了早期鳍鱼中存在功能性肺相关基因。此外，我们在功能上验证了一个有颌脊椎动物的心血管发育的高度保守的元素的重要作用。我们的研究结果表明，有颌脊椎动物的祖先已经具有支持空气呼吸的心肺系统的潜在基因网络。
Rich fossil evidence suggests that many traits and functions related to terrestrial evolution were present long before the ancestor of lobe- and ray-finned fishes. Here, we present genome sequences of the bichir, paddlefish, bowfin, and alligator gar, covering all major early divergent lineages of ray-finned fishes. Our analyses show that these species exhibit many mosaic genomic features of lobe- and ray-finned fishes. In particular, many regulatory elements for limb development are present in these fishes, supporting the hypothesis that the relevant ancestral regulation networks emerged before the origin of tetrapods. Transcriptome analyses confirm the homology between the lung and swim bladder and reveal the presence of functional lung-related genes in early ray-finned fishes. Furthermore, we functionally validate the essential role of a jawed vertebrate highly conserved element for cardiovascular development. Our results imply the ancestors of jawed vertebrates already had the potential gene networks for cardio-respiratory systems supporting air breathing.