Thymic aplasia with possible graft-versus-host disease.
Thymic aplasia with possible graft-versus-host disease.
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胸腺发育不全可能伴有移植物抗宿主病。
DOI：
10.1016/s0022-3476(75)80223-x
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
J. Kersey
中科院分区：
文献类型：
--
作者：
T. K. Chen;C. Clawson;E. Yunis;J. Kersey
9 0 4简短的临床和实验室观察《儿科杂志》1975年6月mia，与患有相同疾病的成人中发现的结果非常相似。[7]白细胞中抗坏血酸浓度的显著增加是根据缺铁性贫血时抗坏血酸的催化活性降低来解释的。治疗7天后WBC中抗坏血酸水平的降低可以解释为抗坏血酸利用的增加。已经表明，在缺铁性贫血中，红细胞中还原型谷胱甘肽（GSH）增加。这种增加的确切机制尚不清楚，但已被解释为保护血红蛋白免受氧化的机制。可以认为，红细胞中抗坏血酸浓度的增加，伴随着铁缺乏，也是为了保护血红蛋白免受氧化，其方式类似于谷胱甘肽。然而，似乎更有可能的是，在缺铁状态下，红细胞中抗坏血酸水平的增加在开始时仅仅与抗坏血酸利用的减少有关，因为红细胞中抗坏血酸的浓度在治疗7天后恢复正常。在缺铁加感染的情况下，白细胞中维生素C的平均浓度没有显着增加。血浆抗坏血酸水平明显低于正常值，可能反映了感染与维生素C的关系。
9 0 4 Brief clinical and laboratory observations The Journal of Pediatrics June 1975 mia, bears close resemblance to that found in adults with the same condition. 7 The significant increase in concentration of ascorbic acid in leukocytes has been explained on the basis of decreased catabolism of ascorbic acid in iron deficiency anemia. Reduction of the ascorbic acid level in WBC after seven days of therapy may be explained by an increase in the utilization of ascorbic acid.It has been shown that in iron deficiency anemia, reduced glutathione (GSH) in red blood cells is increased. 12 The exact mechanism of this increase is not well understood, but has been explained as a mechanism to protect hemoglobin from oxidation. It may be considered that the increased concentration of ascorbic acid in red blood cells, accompanying iron deficiency, is also for the protection of hemoglobin from oxidation in a manner analogous to that suggested for glutathione. It seems more likely, however, that in the iron deficiency state, the increase in the level of ascorbic acid in the erythrocyte at the beginning is simply related to a decreased utilization of ascorbic acid, since the concentration of ascorbic acid in the erythrocyte returned to normal following seven days of therapy. In cases of iron deficiency plus infection, the mean concentration of vitamin C in leukocytes was not increased significantly. The plasma level of ascorbic acid was significantly lower than the normal value, possibly reflecting a relationship between infection and vitamin C.