Gender susceptibility to mycobacterial infections in patients with non-CF bronchiectasis.
Gender susceptibility to mycobacterial infections in patients with non-CF bronchiectasis.
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DOI：
10.1016/j.ijmyco.2015.05.002
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发表时间：
2015-06
影响因子：
1.2
通讯作者：
Sadikot RT
中科院分区：
文献类型：
--
作者：
Mirsaeidi M;Sadikot RT
非结核分枝杆菌（NTM）是一种环境微生物，在免疫功能低下和免疫功能正常的患者中引起多种疾病。流行病学数据表明，全球NTM感染发病率呈上升趋势。也有人指出，NTM感染倾向于发生在绝经后妇女。最近的一项研究表明，在非cf性支气管扩张患者中，老年女性患者和低体重指数患者中NTM分离的概率明显更高。然而，这些性别差异和形态表型的因果关系机制仍然是谜。本研究回顾了可能为支气管扩张和NTM患者的性别易感性和形态表型提供线索的数据和可能的机制。
Non-tuberculous mycobacteria (NTM) are environmental microbes that cause a variety of diseases both in immunocompromised and immunocompetent patients. Epidemiologic data indicate that there has been a global rise in the incidence of NTM infections. It has also been noted that NTM infections have a predilection to occur in postmenopausal women. In a recent study, it was demonstrated that in patients with non-CF bronchiectasis the probability of NTM isolation was significantly higher in elderly female patients and in those with a low body mass index. However, the mechanisms of causality of these gender differences and morpho-phenotypes remain enigmatic. The present study reviews the data and plausible mechanisms which might provide clues to this gender susceptibility and morphophenotypes of patients with bronchiectasis and NTM.