Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models.
Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models.
复制标题
DOI：
10.5483/bmbrep.2011.44.3.158
复制
发表时间：
2011-03
期刊：
影响因子：
3.8
通讯作者：
Parada LF
中科院分区：
文献类型：
--
作者：
Lim SK;Llaguno SR;McKay RM;Parada LF
胶质瘤是中枢神经系统最常见的原发性恶性肿瘤，其中多形性胶质母细胞瘤（GBM）最为常见，侵袭性最强。尽管在过去几十年中进行了大量的基础和临床研究，但患有这种疾病的患者的中位生存期仍然在一年左右。最近的研究表明，GBM含有一个肿瘤细胞亚群，显示干细胞特征，因此可能是体内肿瘤生长的原因。我们将总结在胶质瘤中异常调节的主要致癌途径，并回顾我们实验室和其他实验室为研究GBM开发的小鼠模型的最新发现。GBM中癌症干细胞的概念及其潜在的治疗意义也将被讨论。
Gliomas are the most frequently occurring primary malignancies in the central nervous system, and glioblastoma multiforme (GBM) is the most common and most aggressive of these tumors. Despite vigorous basic and clinical studies over past decades, the median survival of patients with this disease remains at about one year. Recent studies have suggested that GBMs contain a subpopulation of tumor cells that displays stem cell characteristics and could therefore be responsible for in vivo tumor growth. We will summarize the major oncogenic pathways abnormally regulated in gliomas, and review the recent findings from mouse models that our laboratory as well as others have developed for the study of GBM. The concept of cancer stem cells in GBM and their potential therapeutic importance will also be discussed.