Horizontal Gene Transfer as a Source of Conflict and Cooperation in Prokaryotes
Horizontal Gene Transfer as a Source of Conflict and Cooperation in Prokaryotes
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DOI：
10.3389/fmicb.2020.01569
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发表时间：
2020-07-17
影响因子：
5.2
通讯作者：
Domingo-Sananes, Maria Rosa
中科院分区：
文献类型：
--
作者：
Hall, Rebecca J.;Whelan, Fiona J.;Domingo-Sananes, Maria Rosa
水平基因转移（HGT）是原核生物进化中最重要的过程之一。 DNA 的共享可以在人群和社区之间传播中性或有益基因以及遗传寄生虫，从而产生自然选择作用的很大一部分变异。在这里，我们强调 HGT 在增强原核生物基因组内部和之间的冲突与合作机会方面的作用。我们讨论水平获得的基因如何相互合作或冲突以及与受体基因组的合作或冲突，从而导致基因共现、回避和依赖的特征模式。然后，我们描述了涉及水平转移基因的相互作用如何影响更高层次（群体、社区和共生体）的合作和冲突。最后，我们考虑了 HGT 对原核生物的好处和缺点，以及它在理解从基因-基因到微生物组水平的冲突与合作方面的基本作用。
Horizontal gene transfer (HGT) is one of the most important processes in prokaryote evolution. The sharing of DNA can spread neutral or beneficial genes, as well as genetic parasites across populations and communities, creating a large proportion of the variability acted on by natural selection. Here, we highlight the role of HGT in enhancing the opportunities for conflict and cooperation within and between prokaryote genomes. We discuss how horizontally acquired genes can cooperate or conflict both with each other and with a recipient genome, resulting in signature patterns of gene co-occurrence, avoidance, and dependence. We then describe how interactions involving horizontally transferred genes may influence cooperation and conflict at higher levels (populations, communities, and symbioses). Finally, we consider the benefits and drawbacks of HGT for prokaryotes and its fundamental role in understanding conflict and cooperation from the gene-gene to the microbiome level.