Sensorimotor Cortex Excitability and Connectivity in Alzheimer's Disease: A TMS-EEG Co-Registration Study
Sensorimotor Cortex Excitability and Connectivity in Alzheimer's Disease: A TMS-EEG Co-Registration Study
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DOI：
10.1002/hbm.23158
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发表时间：
2016-06-01
影响因子：
4.8
通讯作者：
Di Lazzaro, Vincenzo
中科院分区：
文献类型：
--
作者：
Ferreri, Florinda;Vecchio, Fabrizio;Di Lazzaro, Vincenzo
几项研究表明，尽管运动症状在阿尔茨海默病（AD）的病程中表现较晚，但运动皮层的神经病理进展与通常被认为是神经退行性过程更具体目标的其他大脑区域相似。有研究表明，运动皮质兴奋性在阿尔茨海默病的早期阶段就增强了，这与疾病的严重程度和进展有关。为了研究早期AD运动皮质功能的神经生理特征，我们将经颅磁刺激（TMS）与脑电图（EEG）相结合。我们证明，在轻度阿尔茨海默病中，尽管缺乏临床明显的运动表现，但感觉运动系统是过度兴奋的。这种现象在特定的时间窗口内引起对刺激的更强反应，可能是由于局部作用的强化电路，而网络活动和连通性减少。这些变化可以解释为一种补偿机制，允许在很长一段时间内保持感觉运动编程和执行，而不管疾病的进展如何。(C) 2016 Wiley期刊公司
Several studies have shown that, in spite of the fact that motor symptoms manifest late in the course of Alzheimer's disease (AD), neuropathological progression in the motor cortex parallels that in other brain areas generally considered more specific targets of the neurodegenerative process. It has been suggested that motor cortex excitability is enhanced in AD from the early stages, and that this is related to disease's severity and progression. To investigate the neurophysiological hallmarks of motor cortex functionality in early AD we combined transcranial magnetic stimulation (TMS) with electroencephalography (EEG). We demonstrated that in mild AD the sensorimotor system is hyperexcitable, despite the lack of clinically evident motor manifestations. This phenomenon causes a stronger response to stimulation in a specific time window, possibly due to locally acting reinforcing circuits, while network activity and connectivity is reduced. These changes could be interpreted as a compensatory mechanism allowing for the preservation of sensorimotor programming and execution over a long period of time, regardless of the disease's progression. (C) 2016 Wiley Periodicals, Inc.