Host epigenetic modifications by oncogenic viruses.
Host epigenetic modifications by oncogenic viruses.
复制标题
通过致癌病毒进行宿主的表观遗传修饰。
DOI：
10.1038/sj.bjc.6603516
复制
发表时间：
2007-01-29
影响因子：
8.8
通讯作者：
Flanagan, J M
中科院分区：
文献类型：
--
作者：
Flanagan, J M
表观遗传改变是大多数人类癌症发生和发展的重要一步，但很难区分引起改变的早期癌症和后来的后果。致癌病毒只能通过表达少量的病毒基因来诱导转化。因此，致癌病毒致癌的机制可能为表观遗传改变在早期癌症发生中的关键提供线索。
Epigenetic alterations represent an important step in the initiation and progression of most human cancers, but it is difficult to differentiate the early cancer causing alterations from later consequences. Oncogenic viruses can induce transformation via expression of only a small number of viral genes. Therefore, the mechanisms by which oncogenic viruses cause cancer may provide clues as to which epigenetic alterations are critical in early carcinogenesis.