Lymphocyte subset reconstitution in pediatric liver recipients induced with steroid-free rabbit anti-human thymocyte globulin.
Lymphocyte subset reconstitution in pediatric liver recipients induced with steroid-free rabbit anti-human thymocyte globulin.
复制标题
用无类固醇兔抗人胸腺细胞球蛋白诱导儿童肝受体的淋巴细胞亚群重建。
DOI：
10.1111/j.1399-3046.2007.00797.x
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发表时间：
2008
影响因子：
1.3
通讯作者：
Sindhi,Rakesh
中科院分区：
文献类型：
--
作者：
Talukdar,Anjan;AshokKumar,Chethan;Farrar,Jennifer;Wilson,Patrick;Janakiramanan,Arun;Tregaskes,Mary;Sindhi,Rakesh
摘要：对 91 名接受无类固醇他克莫司治疗和兔抗人胸腺细胞球蛋白诱导的儿童的淋巴细胞亚群进行多次测量，结果表明 T 细胞毒性细胞的早期重建，以及所有其他亚群的逐渐重建，并在一年后完成。易发生排斥反应的儿童在肝移植前表现出明显较高的淋巴细胞和所有亚群计数，这可能是增强基线免疫能力的基础之一。
Abstract:Multiple measurements of lymphocyte subsets in 91 children treated with steroid‐free tacrolimus, and rabbit anti‐human thymocyte globulin induction demonstrate early reconstitution of T‐cytotoxic cells, and gradual reconstitution of all other subsets, which is complete after one yr. Rejection‐prone children demonstrate significantly higher counts of lymphocytes and all subsets prior to liver transplantation, and may exemplify one basis for enhanced baseline immunocompetence.