Insights into the spatial distribution of lipid-rich plaques in relation to coronary artery bifurcations: an in-vivo optical coherence tomography study
Insights into the spatial distribution of lipid-rich plaques in relation to coronary artery bifurcations: an in-vivo optical coherence tomography study
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深入了解与冠状动脉分叉相关的富含脂质斑块的空间分布：体内光学相干断层扫描研究
DOI：
10.1097/mca.0000000000000188
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发表时间：
2015-03
影响因子：
1.8
通讯作者：
Jang Ik-Kyung
中科院分区：
文献类型：
--
作者：
Jia Haibo;Hu Sining;Uemura Shiro;Park Seung-Jung;Jang Yangsoo;Prasad Abhiram;Lee Stephen;Soeda Tsunenari;Abtahian Farhad;Vergallo Rocco;Tian Jinwei;Lee Hang;Stone Peter H.;Yu Bo;Jang Ik-Kyung
目的 本研究的目的是利用频域光学相干断层扫描研究冠状动脉分叉处易损斑块的空间位置。背景 与冠状动脉分叉相关的易损斑块几何位置的体内数据有限。材料和方法 总共对 40 名左前降支分叉患者进行了研究。比较了与侧分支相关的五个区域的斑块特征：相对分流器（OFD）；分叉位点（BF）；主分支近侧（MBP）；侧支近侧（SBP）；和分流器（FD）。频域光学相干断层扫描用于斑块表征。结果在44个分叉的220个区域中检测到72个富含脂质的斑块和15个薄帽纤维粥样斑块（TCFA）。总体而言，主枝面比侧枝面具有更多的脆弱特征。 FD 很少受到脂质积累的影响。 OFD 显示富含脂质斑块的患病率最高 [47.7% (OFD) vs. 45.5% (MBP)、43.2% (BF)、18.2% (SBP) 和 9.1% (FD)，P<0.0001] 和 TCFA [20.5% (OFD) vs. 6.8% (MBP)、6.8% (BF)、2.2% （收缩压）， 和 0.0% (FD)，P<0.001] 和最薄的纤维帽 [88.7±43.7 &mgr;m (OFD) 对比 123.5±62.7 &mgr;m (MBP)、149.6±77.0 &mgr;m (BF)、157.4±65.4 &mgr;m (收缩压)、163.6±76.9 &mgr;m (FD)，P=0.002]与其他地区相比。结论脂质堆积多发生在侧枝对面区域。 TCFA 主要分布在 OFD 区域，而 FD 很少受到影响。
Objectives The aim of this study was to investigate the spatial location of vulnerable plaques at coronary artery bifurcations using frequency domain-optical coherence tomography. Background In-vivo data on geometric location of vulnerable plaques in relation to coronary bifurcation are limited. Materials and methods A total of 40 patients with left anterior descending artery bifurcation were studied. Plaque characteristics in five regions in relation to a side branch were compared: opposite flow divider (OFD); bifurcation site (BF); main branch side proximal (MBP); side branch side proximal (SBP); and flow divider (FD). Frequency domain-optical coherence tomography was used for plaque characterization. Results Seventy-two lipid-rich plaques and 15 thin-cap fibroatheroma (TCFA) were detected in 220 regions of 44 bifurcations. Overall, the main branch side had more vulnerable characteristics compared with the side branch side. The FD was rarely affected by lipid accumulation. The OFD showed the highest prevalence of lipid-rich plaques [47.7% (OFD) vs. 45.5% (MBP), 43.2% (BF), 18.2% (SBP), and 9.1% (FD), P<0.0001] and TCFA [20.5% (OFD) vs. 6.8% (MBP), 6.8% (BF), 2.2% (SBP), and 0.0% (FD), P<0.001] and the thinnest fibrous cap [88.7±43.7 &mgr;m (OFD) vs. 123.5±62.7 &mgr;m (MBP), 149.6±77.0 &mgr;m (BF), 157.4±65.4 &mgr;m (SBP), and 163.6±76.9 &mgr;m (FD), P=0.002] compared with other regions. Conclusion Lipid accumulation tends to develop in the zone opposite the side branch. TCFA was localized predominantly in the region OFD, whereas FD was rarely affected.
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影响因子：
37.8
作者：
Wang, JC;Normand, SLT;Kuntz, RE
通讯作者：
Kuntz, RE
影响因子：
8.3
作者：
Lee, Sang-Wook;Antiga, Luca;Steinman, David A.
通讯作者：
Steinman, David A.
影响因子：
37.8
作者：
Chatzizisis, Yiannis S.;Jonas, Michael;Stone, Peter H.
通讯作者：
Stone, Peter H.
影响因子：
6.2
作者：
Papadopoulou, Stella-Lida;Brugaletta, Salvatore;de Feyter, Pim J.
通讯作者：
de Feyter, Pim J.
影响因子：
4.8
作者：
McDaniel, Michael C.;Galbraith, Erin M.;Samady, Habib
通讯作者：
Samady, Habib