Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors
Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors
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DOI：
10.1016/j.bbr.2010.08.042
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发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Fujiwara, Michihiro
中科院分区：
文献类型：
--
作者：
Higuchi, Sei;Ohji, Makiko;Fujiwara, Michihiro
本研究的目的是研究HFD的偏好和2-花生四烯酸甘油（2-AG），内源性大麻素之间的关系。3天的HFD摄入诱导HFD的偏好，这是由CB 1拮抗剂，O-2050抑制。此外，下丘脑2-AG增加后，3天的HFD摄入。我们的结果表明，对HFD的偏好是通过下丘脑中2-AG的增加激活CB 1受体而诱导的。(C)2010 Elsevier B. V.保留所有权利。
The aim of the present study is to examine the relationship between preference for HFD and 2-arachidonoylglycerol (2-AG), endogenous cannabinoid. The 3-day HFD intake induced preference for HFD, which was suppressed by CB1 antagonist, O-2050. Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus. (C) 2010 Elsevier B.V. All rights reserved.