Motor representation of the hand in the human cortex: an f-MRI study with a conventional 1.5 T clinical unit
Motor representation of the hand in the human cortex: an f-MRI study with a conventional 1.5 T clinical unit
复制标题
DOI：
10.1007/bf00713853
复制
发表时间：
1998-10-01
期刊：
影响因子：
--
通讯作者：
Tassinari, G
中科院分区：
文献类型：
--
作者：
Beltramello, A;Cerini, R;Tassinari, G
本研究的目的是显示一个梯度的可能双边激活的运动的非优势与优势的手，以及复杂与简单的手运动所涉及的领域。一个标准的1.5 T磁共振成像（MRT）系统已被用来定位皮质运动手区，使用血氧水平依赖的对比度（BOLDc）技术和单节快速低角度拍摄（FLASH）成像。10名正常的右撇子志愿者参加了这项研究。运动任务包括两只手的简单（屈伸）手指运动和非优势手的复杂运动（重复的、预先计划好的顺序中的手指与拇指的相对）。简单运动引起对侧的初级运动区（MA）激活;仅观察到非优势手的同侧激活。补充运动区（SMA）也被激活，对侧患病率明显。双侧激活的比例MA没有改变与复杂的运动的非优势手，而SMA以及外侧运动前区在很大程度上双侧激活在这项任务中。总之，同侧MA被激活的运动-即使是简单的-与非优势手执行。对于复杂的运动，存在广泛的功能活动，涉及对侧和同侧SMA。
The purpose of this study was to show a gradient of possible bilateral activation for movements of the non-dominant vs, dominant hand, as well as for areas involved in complex vs. simple hand movements. A standard 1.5 T magnetic resonance imaging (MRT) system has been utilized to localize the cortical motor hand areas, using the blood oxygen level dependent contrast (BOLDc) technique and single-section fast low-angle shot (FLASH) imaging. Ten normal right-handed subjects volunteered for the study. The motor tasks consisted of simple (flexion-extension) finger movements of either hand, and complex movements (finger-to-thumb opposition in a repeating, pre-planned sequence) of the non-dominant hand.Simple movements caused contralateral activation of the primary motor area (MA); ipsilateral activation was observed for the non-dominant hand only. Supplementary motor area (SMA) was also activated, with a clear contralateral prevalence. The ratio of bilateral activation of MA did not change with complex movements of the non-dominant hand, while SMA as well as lateral premotor area were largely bilaterally activated in this task. In conclusion, the ipsilateral MA is activated for movements - even simple - performed with the non-dominant hand. There is widespread functional activity, involving both contralateral and ipsilateral SMA, for complex movements.