B-CELL MITOGENIC PROPERTIES OF THYMUS-INDEPENDENT ANTIGENS
B-CELL MITOGENIC PROPERTIES OF THYMUS-INDEPENDENT ANTIGENS
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DOI：
10.1038/newbio245012a0
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发表时间：
1973-01-01
期刊：
影响因子：
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通讯作者：
MOLLER, G
中科院分区：
文献类型：
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作者：
COUTINHO, A;MOLLER, G
已知某些抗原在胸腺源性(T)淋巴细胞缺失时具有免疫原性1 - 5。对此的一种极端解释是，所有抗原基本上都与胸腺无关，而与之相反的观点是否认这种抗原存在的实验证据。胸腺独立性的另一种解释是基于这些分子的结构，其特征是重复抗原决定因子。这种特殊的结构使分子有可能与B细胞的免疫球蛋白受体建立多重相互作用，从而引起B细胞的激活。
CERTAIN antigens are known to be immunogenic in the absence of thymus-derived (T) lymphocytes1–5. One extreme explanation of this is that all antigens are fundamentally thymus-independent, whereas the contrary view is to deny the experimental evidence for the existence of this type of antigen6. Another explanation for thymus-independency is based on the structure of these molecules, which are characterized by repeating antigenic determinants. This special structure would make it possible for the molecules to establish multiple interactions with the immunoglobulin receptors of the B cells and thus cause their activation7.