The dilution effect limits plasmid horizontal transmission in multispecies bacterial communities.
The dilution effect limits plasmid horizontal transmission in multispecies bacterial communities.
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稀释效应限制了质粒在多物种细菌群落中的水平传播。
DOI：
10.1099/mic.0.001086
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Brockhurst MA
中科院分区：
文献类型：
--
作者：
Kottara A;Carrilero L;Harrison E;Hall JPJ;Brockhurst MA
通过在物种之间转移重要的生态特征，质粒驱动细菌宿主的基因组分化和进化创新。细菌群落通常是多样的，并含有多种共存的质粒，但在多物种群落中的质粒的动态知之甚少。在这里，我们表明，使用实验多物种社区包含两个质粒，细菌多样性限制了水平传播的质粒由于“稀释效应”，这是一种流行病学现象，即生活在不太熟练的宿主物种减少了预期的感染风险的焦点宿主物种。此外，质粒的水平传播也受到质粒多样性的影响，因此，从携带两种质粒的共感染宿主细胞中，质粒接合的速率降低。在不同的微生物群落中，质粒传播可能受到稀释效应和质粒-质粒相互作用的限制，从而降低了水平传播的速率。
By transferring ecologically important traits between species, plasmids drive genomic divergence and evolutionary innovation in their bacterial hosts. Bacterial communities are often diverse and contain multiple coexisting plasmids, but the dynamics of plasmids in multi-species communities are poorly understood. Here, we show, using experimental multi-species communities containing two plasmids, that bacterial diversity limits the horizontal transmission of plasmids due to the ‘dilution effect’; this is an epidemiological phenomenon whereby living alongside less proficient host species reduces the expected infection risk for a focal host species. In addition, plasmid horizontal transmission was also affected by plasmid diversity, such that the rate of plasmid conjugation was reduced from co-infected host cells carrying both plasmids. In diverse microbial communities, plasmid spread may be limited by the dilution effect and plasmid–plasmid interactions, reducing the rate of horizontal transmission.