Catalytic insertion of aldehydes into dihalonitroacetophenones via sequential bond scission-aldol reaction-acyl transfer.
Catalytic insertion of aldehydes into dihalonitroacetophenones via sequential bond scission-aldol reaction-acyl transfer.
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DOI：
10.1039/c5cc09753c
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发表时间：
2016-02-28
期刊：
影响因子：
--
通讯作者：
Wolf C
中科院分区：
文献类型：
--
作者：
Ding R;Wolf C
介绍了一种以高达99%的产率和100%的原子经济性提供二卤代硝醇的催化方法。二卤代硝基苯乙酮的原位裂解得到硝酸盐，这些硝酸盐在路易斯酸催化下与醛加成。最终的苯甲酰化使序列不可逆，并重新生成键断裂和酰基转移剂。
A catalytic process that provides dihalogenated nitro alcohols in up to 99% yield and with 100% atom economy is described. In-situ cleavage of dihalonitroacetophenones affords nitronates that undergo Lewis acid catalyzed addition to aldehydes. Final benzoylation renders the sequence irreversible and regenerates the bond scission and acyl transfer agent.