Cephalic phase responses to sweet taste
Cephalic phase responses to sweet taste
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DOI：
10.1093/ajcn/65.3.737
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发表时间：
1997-03-01
影响因子：
7.1
通讯作者：
LouisSylvestre, J
中科院分区：
文献类型：
--
作者：
Abdallah, L;Chabert, M;LouisSylvestre, J
据报道，非营养性甜味剂的甜味通过头相胰岛素释放(CPIR)机制增加饥饿感和食物摄入量。我们以营养甜味片和非营养甜味片为刺激物，研究了口腔甜味对CPIR和其他与糖代谢相关的指标的影响。午餐时间，12名体重正常的男性吸食蔗糖、阿斯巴甜多聚葡萄糖或无糖多聚葡萄糖片剂(3克)，时间为5分钟，不加任何调味品。这三种刺激以平衡的顺序给予，每隔一周在单独的一天进行。开始吸血前和吸血后分别连续采血45分钟和25分钟，每隔1分钟采血一次。血糖、胰岛素和胰高血糖素浓度的自发波动被评估为在基线期间脂肪酸浓度的增量(斜率)。基线的性质(波动：葡萄糖、胰岛素和胰高血糖素；斜率：脂肪酸)在分析暴露后事件时被考虑在内。三种刺激后均未观察到CPIR，且对血浆胰高血糖素或脂肪酸浓度无明显影响。然而，在所有三种刺激后，血糖和胰岛素都有显著下降。仅在吸食蔗糖片剂后，血糖和胰岛素浓度分别在吸吮开始后17分钟和19分钟开始升高。综上所述，本研究提示甜味无味片剂提供的口腔刺激不足以诱导CPIR。
The sweet taste of nonnutritive sweeteners has been reported to increase hunger and food intake through the mechanism of cephalic-phase insulin release (CPIR). We investigated the effect of oral sensation of sweetness on CPIR and other indexes associated with glucose metabolism using nutritive and nonnutritive sweetened tablets as stimuli. At lunchtime, 12 normal-weight men sucked for 5 min a sucrose, an aspartame-poly dextrose, or an unsweetened polydextrose tablet (3 g) with no added flavor. The three stimuli were administered in a counterbalanced order, each on a separate day at 1-wk intervals. Blood was drawn continuously for 45 min before and 25 min after the beginning of sucking and samples were collected at 1-min intervals. Spontaneous oscillations in glucose, insulin, and glucagon concentrations were assessed as were increments (slopes) of fatty acid concentrations during the baseline period. The nature of the baseline (oscillations: glucose, insulin, and glucagon; and slopes: fatty acids) was taken into account in the analyses of postexposure events. No CPIR and no significant effect on plasma glucagon or fatty acid concentrations were observed after the three stimuli. However, there was a significant decrease in plasma glucose and insulin after all three stimuli. Only the consumption of the sucrose tablet was followed by a postabsorptive increase in plasma glucose and insulin concentrations starting 17 and 19 min, respectively, after the beginning of sucking. In conclusion, this study suggested that oral stimulation provided by sweet nonflavored tablets is not sufficient for inducing CPIR.