The Early Fracture Hematoma and Its Potential Role in Fracture Healing
The Early Fracture Hematoma and Its Potential Role in Fracture Healing
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DOI：
10.1089/ten.teb.2009.0687
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发表时间：
2010-08-01
影响因子：
6.4
通讯作者：
Duda, Georg N.
中科院分区：
文献类型：
--
作者：
Kolar, Paula;Schmidt-Bleek, Katharina;Duda, Georg N.
关于骨折血肿的效力和潜力的研究已开始受到越来越多的关注。但目前关于骨折血肿的性质和成分的相关文献还很少。这篇综述简要总结了骨折再生愈合过程以及骨骼和免疫系统之间的密切相互作用。还讨论了免疫细胞在伤口愈合中的作用，以阐明它们在再生过程中参与免疫过程。我们试图描述目前关于骨折血肿作为骨折愈合再生过程的初始阶段的知识状况。该综述讨论了更好地了解血肿中的免疫反应如何对骨组织工程策略产生影响。我们通过强调对愈合初始阶段的额外研究如何使我们能够更好地区分炎症的有害和有益方面来总结本综述，从而促进改进骨折治疗策略。
Research regarding the potency and potential of the fracture hematoma has begun to receive increasing attention. However, currently there is a paucity of relevant literature on the capability and composition of the fracture hematoma. This review briefly summarizes the regenerative fracture healing process and the close interplay between the skeletal and immune systems. The role of immune cells in wound healing is also discussed to clarify their involvement in immunological processes during regeneration. We attempt to describe the current state of knowledge regarding the fracture hematoma as the initial stage of the regenerative process of fracture healing. The review discusses how a better understanding of immune reactions in the hematoma may have implications for bone tissue engineering strategies. We conclude the review by emphasizing how additional investigations of the initial phase of healing will allow us to better differentiate between deleterious and beneficial aspects of inflammation, thereby facilitating improved fracture treatment strategies.