Radiation dose-effect relations and local recovery in perfusion for patients with non-small-cell lung cancer
Radiation dose-effect relations and local recovery in perfusion for patients with non-small-cell lung cancer
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DOI：
10.1016/s0360-3016(00)00454-5
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发表时间：
2000-06-01
影响因子：
7
通讯作者：
Lebesque, JV
中科院分区：
文献类型：
--
作者：
Theuws, JCM;Baas, P;Lebesque, JV
目的：确定非小细胞肺癌 (NSCLC) 患者因放疗引起的肺灌注和密度变化的局部剂量效应关系，并量化再灌注的影响。方法和材料：对于 25 名 NSCLC 患者和 81 名健康肺部患者的参考组，在放疗前后进行了配准的单光子发射计算机断层扫描 (SPECT) 肺灌注和 CT 扫描。计算灌注和CT密度变化的平均剂量效应关系，并与参考组的剂量效应关系进行比较。根据这些剂量效应关系，预测每位患者的 RT 后灌注，并与测量的 RT 后灌注进行比较。结果：NSCLC 患者灌注良好的肺部区域显示出与参考患者相同的剂量效应关系。通过比较预测和测量的治疗后灌注扫描，可以确定 25 名 NSCLC 患者中的 18 名的再灌注区域，但没有确定参考患者的再灌注区域。结论：NSCLC 患者灌注良好的肺组织在辐射方面表现得与健康肺组织相似。灌注和 CT 密度的剂量效应关系扩展到高达 80 Gy 的剂量，由于局部再灌注，灌注不良的肺部区域的辐射损伤小于预期。 (C) 2000 爱思唯尔科学公司。
Purpose: To determine local dose-effect relations for lung perfusion and density changes due to irradiation for patients with non-small-cell lung cancer (NSCLC) and to quantify the effect of reperfusion.Methods and Materials: For 25 NSCLC patients and a reference group of 81 patients with healthy lungs, registered single photon emission computed tomography (SPECT) lung perfusion and CT scans were made, before and after radiotherapy. Average dose-effect relations for perfusion and CT-density changes were calculated and compared with the dose-effect relation of the reference group. On the basis of these dose-effect relations, the post-RT perfusion was predicted for each patient and compared to the measured post-RT perfusion,Results: Well-perfused lung regions of the NSCLC patients showed the same dose-effect relation as the reference patients. By comparing predicted and measured post-treatment perfusion scans, regions of reperfusion could be determined for 18 of 25 NSCLC patients but for none of the reference patients.Conclusion: Well-perfused lung tissue of patients with NSCLC behaves like healthy lung tissue with respect to radiation. The dose-effect relation for perfusion and CT density was extended for doses up to 80 Gy, Radiation damage in poorly perfused lung regions was less than predicted as a consequence of local reperfusion. (C) 2000 Elsevier Science Inc.