SiRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells
SiRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells
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DOI：
10.2131/jts.32.581
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发表时间：
2007-12-01
影响因子：
2
通讯作者：
Naganuma, Akira
中科院分区：
文献类型：
--
作者：
Hwang, Gi-Wook;Hayashi, Tatsuya;Naganuma, Akira
我们使用靶向8，500个人类基因的siRNA文库进行功能性基因筛选，以鉴定参与细胞对甲状腺激素易感性的蛋白质。筛选显示，通过siRNA下调磷脂酰肌醇聚糖B类（PIG B）基因可使HEK 293细胞对甲基汞产生抗性。
We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to inethylinercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.