The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions.
The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions.
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DOI：
10.1038/srep09642
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发表时间：
2015-04-10
影响因子：
4.6
通讯作者：
Basu S
中科院分区：
文献类型：
--
作者：
Lu K;Basu S
Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). Therefore drugs targeting VEGFA/VEGFR-2 are being presently used in the clinics for treatment of several types of solid malignant tumours. We here in report that low dose of chebulagic acid (CA), a hydrolysable tannin found in myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, migration, tube formation and thereby, angiogenesis by suppressing VEGFR-2 phosphorylation. CA may thus be an effective and useful natural inhibitor of VEGFA mediated angiogenesis.
