Health effects of phloretin: from chemistry to medicine
Health effects of phloretin: from chemistry to medicine
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DOI：
10.1007/s11101-017-9500-x
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发表时间：
2017-06-01
影响因子：
7.7
通讯作者：
Nabavi, Seyed Mohammad
中科院分区：
文献类型：
--
作者：
Behzad, Sahar;Sureda, Antoni;Nabavi, Seyed Mohammad
二氢查尔酮是一类次生代谢产物，其在生物学和药理学方面的应用需求正在迅速增长。根皮黄素是一种最著名和丰富的二氢查尔酮，其特征是存在2,6-二羟基苯乙酮药效团。它是一种多功能分子，具有抗癌、抗破骨、抗真菌、抗病毒、抗炎、抗菌和雌激素活性，能够增加生物膜的流动性和给药药物的渗透性。在这篇综述中，我们对现有文献进行了批判性的评估，涉及到皮黄素的有益作用和细胞内信号级联的激活/阻断。此外，我们还提供了有关其化学性质、来源和生物利用度的有用信息。
Dihydrochalcones are a class of secondary metabolites, whose demand in biological and pharmacological applications is rapidly growing. Phloretin is one of the best known and abundant dihydrochalcone characterized by the presence of 2,6-dihydroxyacetophenone pharmacophore. It is a versatile molecule with anticancer, antiosteoclastogenic, antifungal, antiviral, anti-inflammatory, antibacterial and estrogenic activities and able to increase the fluidity of biological membranes and penetration of administered drugs. In this review we have performed a critical evaluation of available literature as far as phloretin beneficial effects and activation/block of intracellular signal cascade are of concern. In addition, we supply useful information on its chemical properties, sources and bioavailability.