The relationship of circulating dehydroepiandrosterone, testosterone, and estradiol to stages of the menopausal transition and ethnicity
The relationship of circulating dehydroepiandrosterone, testosterone, and estradiol to stages of the menopausal transition and ethnicity
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DOI：
10.1210/jc.87.8.3760
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发表时间：
2002-08-01
影响因子：
5.8
通讯作者：
Sowers, MF
中科院分区：
文献类型：
--
作者：
Lasley, BL;Santoro, N;Sowers, MF
在这份报告中，3029名妇女的年龄在42岁至54岁之间的五个民族进行了为期2年的研究。对数循环硫酸脱氢表雄酮（DHEAS）浓度在中国人和日本人中最高，在非洲裔美国人和西班牙裔美国人中最低，在校正年龄、吸烟和对数体重指数（BMI）后，这种模式仍然存在。除日本女性外，对数BMI与对数循环DHEAS呈负相关。这种关联的程度因种族而异，对数循环DHEAS水平的下降与较高的对数BMI在中国人中最陡峭，在西班牙人中最不陡峭。日本人的log DHEAS和log BMI之间呈正相关。DHEAS水平在绝经过渡期没有以稳定的速度下降，在一些妇女中短暂增加，平均而言，在过渡到晚期围绝经期。中国人、西班牙人和日本人的这些增加往往大于非洲裔美国人和高加索人，尽管相互作用在统计学上不显著。循环睾酮的变化，在较小程度上，雌二醇与DHEAS的变化相关。这些数据对于了解绝经过渡期的内分泌学，确定卵巢功能下降期间肾上腺类固醇产生的关系以及确定老年妇女补充DHEAS的基本原理具有重要意义。
In this report, 3029 women between the ages of 42 and 54 yr from five ethnic groups were studied for 2 yr. Log circulating dehydroepiandrosterone sulfate (DHEAS) concentrations were highest among Chinese and Japanese and lowest among African Americans and Hispanics, and this pattern persisted after adjustment for age, smoking, and log body mass index (BMI). With the exception of Japanese women, log BMI was negatively related to log circulating DHEAS. The magnitude of this association varied by ethnic group, and the decline in log circulating DHEAS levels with higher log BMI was steepest for Chinese and least steep for Hispanics. The relationship between log DHEAS and log BMI was positive for Japanese. DHEAS levels did not decline at a steady rate during the menopausal transition and transiently increased in some women and increased, on average, during the transition to late peri-menopause. These increases tended to be larger for Chinese, Hispanic, and Japanese than for African Americans and Caucasians, although the interactions were not statistically significant. Changes in circulating testosterone and, to a lesser extent, estradiol were correlated to changes in DHEAS. These data have importance in understanding the endocrinology of the menopausal transition, defining the relationship of adrenal steroid production during declining ovarian function and determining a rationale regarding DHEAS supplementation for older women.