Undergraduate Analytical Chemistry: Method Development and Results of the Analysis of Bismuth in Pharmaceuticals
Undergraduate Analytical Chemistry: Method Development and Results of the Analysis of Bismuth in Pharmaceuticals
复制标题
本科分析化学：药物中铋分析的方法开发和结果
DOI：
10.1080/00387010.2010.510764
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发表时间：
2010
影响因子：
1.7
通讯作者：
R. Kimbrough
中科院分区：
文献类型：
--
作者：
M. Koether;Brent Ferguson;R. Kimbrough
摘要建立了三种不同的分析方法，用于分析口服液药物混悬液中水杨酸铋的浓度。这些方法是利用外校准法和标准加入法的紫外-可见光谱、火焰原子吸收光谱和EDTA络合滴定。所有这三种方法都是由本科生在分析化学实验室的班级环境中在一个3小时的时间内进行的，结果在美国药典列出的90.0-110.0%的允许范围内。观察了三种方法在灵敏度、精密度、样本量、时间和试剂使用方面的差异。
ABSTRACT Three different methods were developed and employed to analyze the concentration of bismuth subsalicylate in an oral liquid pharmaceutical suspension. These methods were UV-Visible spectroscopy utilizing the external calibration method and the standard addition method, flame atomic absorption spectroscopy, and complexometric titration with EDTA. All three methods were conducted within one 3-hr period by undergraduate students in analytical chemistry laboratory class settings and produced results within the allowable range of 90.0–110.0% as listed in the United States Pharmacopeia. Differences in sensitivity, precision, sample size, time, and reagent use between the three methods were observed.