Effects of marijuana on performance of a computerized cognitive-neuromotor test battery.
Effects of marijuana on performance of a computerized cognitive-neuromotor test battery.
复制标题
大麻对计算机认知神经运动测试电池性能的影响。
DOI：
10.1016/0165-1781(94)90031-0
复制
发表时间：
1994
影响因子：
11.3
通讯作者：
Johnson,K
中科院分区：
文献类型：
--
作者：
Wilson,WH;Ellinwood,EH;Mathew,RJ;Johnson,K
为了评估计算机化认知-神经运动测试组合在评估大麻(Δ-9-四氢大麻酚)效果方面的敏感性，我们对10名有吸食大麻经验的健康男性志愿者进行了研究。在进行了广泛的操作任务训练后，根据随机双盲重复测量设计，每个受试者在吸食含有1.75%THC、3.55%THC或安慰剂的香烟后，分别在三天内进行测试。在吸烟前、吸烟后30分钟、90分钟和150分钟进行测试。在所采用的五项任务中，有记忆的数字符号替代测试和反应时任务是对大麻效应最敏感的测量。我们考察了变异系数和效应大小作为不同类型任务敏感度指标的有用性。
To evaluate the sensitivity of a computerized cognitive-neuromotor test battery in assessing the effects of marijuana (Δ-9-tetrahydrocannabinol [THC]), we conducted a study of 10 healthy male volunteers who were experienced marijuana smokers. After extensive training on the performance tasks, each subject was tested on three separate days after smoking a cigarette containing either 1.75% THC, 3.55% THC, or placebo according to a randomized double-blind repeated measures design. Testing was carried out before smoking and 30, 90, and 150 minutes after smoking the cigarette. Of the five tasks employed, the digit-symbol substitution test with memory and the reaction time task were the measures most sensitive to effects of marijuana. We examined the usefulness of the coefficient of variation and effect size as indices of sensitivity to be used across different types of tasks.