Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction
Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction
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DOI：
10.1038/nn1583
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发表时间：
2005-11-01
影响因子：
25
通讯作者：
LaForge, KS
中科院分区：
文献类型：
--
作者：
Kreek, MJ;Nielsen, DA;LaForge, KS
基因变异可能在一定程度上导致了复杂的个性和生理特征--如冲动、冒险和对压力的反应--以及相当大比例的易患上瘾疾病。此外，个性和生理特征本身可能会不同地影响成瘾的不同阶段，按时间顺序定义为开始吸毒、经常吸毒、成瘾/依赖和可能复发。在这里，我们集中在这些人格和生理特征的遗传变异研究的最新方法，以及它们对成瘾疾病的影响和相互作用。
Genetic variation may partially underlie complex personality and physiological traits-such as impulsivity, risk taking and stress responsivity-as well as a substantial proportion of vulnerability to addictive diseases. Furthermore, personality and physiological traits themselves may differentially affect the various stages of addiction, defined chronologically as initiation of drug use, regular drug use, addiction/dependence and potentially relapse. Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases.