Water-Soluble Non-Classical Benzene Mimetics
Water-Soluble Non-Classical Benzene Mimetics
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DOI：
10.1002/anie.202000548
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发表时间：
2020-03-18
影响因子：
16.6
通讯作者：
Mykhailiuk, Pavel K.
中科院分区：
文献类型：
--
作者：
Levterov, Vadym V.;Panasyuk, Yaroslav;Mykhailiuk, Pavel K.
开发了新一代饱和苯模拟物- 2-氧沙环[2.1.1]己烷。这些化合物被设计成具有改善水溶性的双环[1.1.1]戊烷的类似物。对2-氧杂环[2.1.1]己烷的晶体学分析表明，它们占据了一个新的化学空间，但与此同时，它们类似于间二取代苯的基序。
A new generation of saturated benzene mimetics, 2-oxabicyclo[2.1.1]hexanes, was developed. These compounds were designed as analogues of bicyclo[1.1.1]pentane with an improved water solubility. Crystallographic analysis of 2-oxabicyclo[2.1.1]hexanes revealed that they occupy a novel chemical space, but, at the same time, resemble the motif of meta-disubstituted benzenes.