EFFECTS OF SUBSTANCE-P ON FUNCTIONALLY IDENTIFIED UNITS IN CAT SPINAL-CORD
EFFECTS OF SUBSTANCE-P ON FUNCTIONALLY IDENTIFIED UNITS IN CAT SPINAL-CORD
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DOI：
10.1016/0006-8993(76)90965-3
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发表时间：
1976-01-01
期刊：
影响因子：
2.9
通讯作者：
HENRY, JL
中科院分区：
文献类型：
--
作者：
HENRY, JL
本文将合成P物质(SSP)对脊髓背角神经元的作用与这些神经元对自然外周刺激的反应联系起来。SSP只对皮肤受到有害辐射热刺激的那些单位产生兴奋作用。SSP还引起了对这种伤害性刺激的兴奋反应的轻微促进，在2例中，导致了对以前不受这种刺激影响的单位的伤害性热的反应。SSP敏感单位与不敏感单位的比例以背角深部最高。SSP兴奋与缓激肽兴奋呈正相关。P物质可能参与兴奋性脊髓突起，其作用可能与伤害性感受有关。
A correlation was made between the effects of synthetic substance P (ssP) on spinal dorsal horn neurons and the responses of these neurons to natural peripheral stimulation. ssP caused excitation only of those units which were excited by noxious radiant heat applied to the skin. ssP also caused a small facilitation of the excitatory response to this noxious stimulus and, in 2 cases, led to a response to noxious heat of units which had previously been unaffected by this stimulus. The ratio of ssP sensitive to insensitive units was highest in the deeper parts of the dorsal horn. Excitation by ssP showed a positive correlation to excitation by bradykinin. Substance P may be involved in excitatory spinal processes, and its actions may be associated specifically with nociception.