Baroreceptor modulation of active cutaneous vasodilation during dynamic exercise in humans.
Baroreceptor modulation of active cutaneous vasodilation during dynamic exercise in humans.
复制标题
人体动态运动期间主动皮肤血管舒张的压力感受器调节。
DOI：
10.1152/jappl.2001.90.4.1464
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Peters,J
中科院分区：
文献类型：
--
作者：
Mack,GW;Cordero,D;Peters,J
在7名受试者中测试了压力感受器在动态过程中卸载通过撤销主动血管扩张剂活性来限制皮肤血管扩张的假说。测量前臂皮肤血流量(激光多普勒测速仪)在有和没有α肾上腺素能血管收缩活性(仅有血管扩张剂)和动脉血压(无创)的皮肤部位的增加，并用来计算皮肤血管电导。受试者进行两种类似的动态运动方案(119±8W)，分别在施加−40毫米汞柱下体负压诱导和不施加压力感受器负荷的情况下进行。下体负压状态在15分钟后被逆转(即，移除或应用)，同时运动继续额外的15分钟。在没有下体负压的运动中，对照组和仅使用血管扩张剂的皮肤部位引发主动皮肤血管扩张所需的体心温度(食道温度)平均分别为0.25±0.08和0.31±0.10°C(SE)，而在没有下体负压的运动中分别增加到0.44±0.10和0.50±0.10°C(P<；0.05)。在运动中，压力感受器卸载延迟了皮肤血管扩张的开始，并限制了仅使用血管扩张剂的皮肤部位的CVC峰值。这些数据支持这样的假设，即在运动过程中，压力感受器的卸载调节了主动的皮肤血管扩张。
The hypothesis that baroreceptor unloading during dynamic limits cutaneous vasodilation by withdrawal of active vasodilator activity was tested in seven human subjects. Increases in forearm skin blood flow (laser-Doppler velocimetry) at skin sites with (control) and without α-adrenergic vasoconstrictor activity (vasodilator only) and in arterial blood pressure (noninvasive) were measured and used to calculate cutaneous vascular conductance (CVC). Subjects performed two similar dynamic exercise (119 ± 8 W) protocols with and without baroreceptor unloading induced by application of −40 mmHg lower body negative pressure (LBNP). The LBNP condition was reversed (i.e., either removed or applied) after 15 min while exercise continued for an additional 15 min. During exercise without LBNP, the increase in body core temperature (esophageal temperature) required to elicit active cutaneous vasodilation averaged 0.25 ± 0.08 and 0.31 ± 0.10°C (SE) at control and vasodilator-only skin sites, respectively, and increased to 0.44 ± 0.10 and 0.50 ± 0.10°C (P< 0.05 compared with without LBNP) during exercise with LBNP. During exercise baroreceptor unloading delayed the onset of cutaneous vasodilation and limited peak CVC at vasodilator-only skin sites. These data support the hypothesis that during exercise baroreceptor unloading modulates active cutaneous vasodilation.