Antimicrobial peptides and bacteriocins: alternatives to traditional antibiotics
Antimicrobial peptides and bacteriocins: alternatives to traditional antibiotics
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DOI：
10.1017/s1466252308001497
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发表时间：
2008-12-01
影响因子：
2.5
通讯作者：
Blecha, Frank
中科院分区：
文献类型：
--
作者：
Sang, Yongming;Blecha, Frank
抗菌肽（Antimicrobial peptides，AMP）是一种普遍存在的基因编码的天然抗生素，近年来在寻找新的抗感染药物方面受到关注。在多细胞生物体中，AMP，如防御素和cathelicidins，提供针对感染的协调保护性应答，并且是脊椎动物先天免疫的主要组分。在单细胞生物中，AMP，如细菌素，起抑制竞争物种的作用。由于许多抗菌肽通过破坏膜完整性来杀死细菌，因此被认为不太可能诱导耐药性，因此抗菌肽作为新型抗微生物药物被广泛评价。本文综述了抗菌肽的抗生素特性，强调其作为传统抗生素替代品的潜力。
Antimicrobial peptides (AMPs) are ubiquitous, gene-encoded natural antibiotics that have gained recent attention in the search for new antimicrobials to combat infectious disease. In multicellular organisms, AMPs, such as defensins and cathelicidins, provide a coordinated protective response against infection and are a principal component of innate immunity in vertebrates. In unicellular organisms, AMPs, such as bacteriocins, function to suppress competitor species. Because many AMPs kill bacteria by disruptions of membrane integrity and are thus thought to be less likely to induce resistance, AMPs are being extensively evaluated as novel antimicrobial drugs. This review summarizes and discusses the antibiotic properties of AMPs highlighting their potential as alternatives to conventional antibiotics.